caa a22 4500 469128364 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573497 doi (NATIONALLICENCE)springer-10.1007/BF00573497 Increased urinary albumin excretion is associated with a cluster of metabolic alterations in type 2 diabetes mellitus [Elektronische Daten] [Sandro Inchiostro, Giovanni Bertoli, Giorgio Zanette, Carlo Donada, Antonio Maccioni, Gabriele Tommasi, Nadia Citroni, Stefano Castagna, Valter Donadon] The relationship between urinary albumin excretion rate (UAE) and some metabolic and haemodynamic characteristics was studied in 62 (50 male, 12 female) type 2 (non-insulin-dependent) diabetic patients, with (26 male, 5 female) and without (24 male, 7 female) ischaemic heart disease (IHD), free from overt diabetic nephropathy. The overall population was subdivided into quartiles on the basis of UAE values (mg/24h): group 1 (16 subjects), 3.3-7 (range); group 2 (15 subjects), 7.22-11.8; group 3 (15 subjects), 11.9-30; group 4 (16 microalbuminuric subjects), 31.7-226. The groups were comparable with regard to age, duration of diabetes and prevalence of smokers. From group 1 to group 4 we found increasing levels of body mass index (BMI) (24.2±0.6, 26.6±0.7, 27.6±0.7, 27.6±0.9 kg/m2;P=0.007), HbA1c (5.99±0.2, 6.45±0.35, 7.02±0.41, 7.4±0.39%;P=0.017), total cholesterol (5.30±0.26, 5.51±0.34, 6.14±0.21, 6.32±0.26 mmol/l;P=0.026), triglycerides (1.37±0.20, 1.67±0.21, 2.07±0.29, 2.55±0.45 mmol/l;P=0.034) and prevalence of hypertension (50%, 67%, 67%, 81%;P=0.088). No significant differences were found between C-peptide, insulin resistance (K index of insulin tolerance test) and high-density lipoprotein (HDL)-cholesterol levels. Groups 1+2 had a lower prevalence of IHD in comparison with groups 3+4 (42% vs 58%,P=0.069). Using multiple regression analysis, only HbA1c was independently associated with log10 UAE in the overall population (P=0.002), including as independent variables age, duration of diabetes, BMI, total cholesterol, triglycerides and mean arterial pressure. In conclusion: (1) type 2 diabetic patients show higher BMI, HbA1c, total cholesterol, triglyceride levels and prevalence of hypertension with increasing UAE, even in the normoalbuminuric range; (2) the prevalence of IHD is higher in the groups with elevated UAE; (3) glycaemic control is the only metabolic characteristic independently associated with UAE. Springer-Verlag, 1992 Albuminuria nationallicence Blood pressure nationallicence Serum lipids nationallicence Cardiovascular disease nationallicence Type 2 (non-insulin-dependent) diabetes mellitus nationallicence Inchiostro Sandro Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Bertoli Giovanni Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Zanette Giorgio Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Donada Carlo Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Maccioni Antonio Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Tommasi Gabriele Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Citroni Nadia Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Castagna Stefano Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Donadon Valter Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 240-245 0940-5429 29:3-4<240 1992 29 592 https://doi.org/10.1007/BF00573497 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573497 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inchiostro Sandro Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Bertoli Giovanni Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Zanette Giorgio Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Donada Carlo Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Maccioni Antonio Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Tommasi Gabriele Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Citroni Nadia Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Castagna Stefano Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 700 1- Donadon Valter Third Internal Medicine and Diabetic Clinic, General Hospital, Via Montereale 24, Pordenone, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 240-245 0940-5429 29:3-4<240 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer