caa a22 4500 469128372 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573480 doi (NATIONALLICENCE)springer-10.1007/BF00573480 Role of glycosaminoglycans in diabetic nephropathy [Elektronische Daten] [Giovanni Gambaro, Bruno Baggio] A number of abnormalities of glycosaminoglycan metabolism have been reported in diabetes mellitus. These include anomalous synthesis, catabolism and sulphation. In this review glycosaminoglycan metabolism in diabetes mellitus is discussed with reference to its possible impact on glomerular basement membrane permeability, and on the physiology and metabolism of glomerular resident cells, specifically of the mesangium. Experimental results demonstrating favourable therapeutic activities of some glycosaminoglycans in mesangioproliferative glomerulitis and diabetic nephropathy are reported. These pharmacological actions do not depend on the well-known anticoagulative activity of glycosaminoglycans, but most probably on their antiproliferative effect. A more complex role of glycosaminoglycans in the pathogenesis of diabetic nephropathy is suggested. Springer-Verlag, 1992 Diabetic nephropathy nationallicence Glomerular basement membrane nationallicence Growth factors nationallicence Glycosaminoglycans nationallicence Heparan sulphate nationallicence Gambaro Giovanni Institute of Internal Medicine, Division of Nephrology, School of Medicine, University of Padua, via Giustiniani 2, I-35128, Padua, Italy aut Baggio Bruno Institute of Internal Medicine, Division of Nephrology, School of Medicine, University of Padua, via Giustiniani 2, I-35128, Padua, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 149-155 0940-5429 29:3-4<149 1992 29 592 https://doi.org/10.1007/BF00573480 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573480 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gambaro Giovanni Institute of Internal Medicine, Division of Nephrology, School of Medicine, University of Padua, via Giustiniani 2, I-35128, Padua, Italy aut NATIONALLICENCE 700 1- Baggio Bruno Institute of Internal Medicine, Division of Nephrology, School of Medicine, University of Padua, via Giustiniani 2, I-35128, Padua, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 149-155 0940-5429 29:3-4<149 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer