caa a22 4500 469128402 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573490 doi (NATIONALLICENCE)springer-10.1007/BF00573490 Dietary factors and progression of diabetic nephropathy [Elektronische Daten] [Giuseppe Maschio, Lamberto Oldrizzi, Carlo Rugiu] The role of dietary factors in patients with type 1 (insulin-dependent) diabetes is reviewed by examining three different aspects: the effect of an acute protein load, the effect of dietary protein restriction on the progression of nephropathy and the metabolic effects of low-protein diets. After an acute protein load some impairment of the "renal functional reserve” may be observed only in patients with type 1 diabetes and overt nephropathy. However, the "renal functional reserve” is not able to give useful indications of the extent of renal damage and the prognosis of the disease. Both short-term and long-term dietary protein restriction are followed by a significant decrease in glomerular filtration rate (GFR) and albuminuria in type 1 diabetics with incipient nephropathy. In patients with overt nephropathy the long-term administration of a low-protein diet is followed by significant reductions in the rate of decline of GFR and in urinary protein excretion only when started at GFR values higher than 45 ml/min. The rate of functional deterioration when dietary treatment is prescribed seems critical in modulating the effects of a low-protein diet. In addition, low-protein diets may exert important metabolic and clinical effects beyond their supposed effect on progression. Clearly, an adequate dietary regimen is only part of the medical treatment in patients with diabetic nephropathy. Springer-Verlag, 1992 Diabetic nephropathy nationallicence Low protein diet nationallicence Maschio Giuseppe Divisione Nefrologia, Ospedale Civile Maggiore, I-37126, Verona, Italy aut Oldrizzi Lamberto Divisione Nefrologia, Ospedale Civile Maggiore, I-37126, Verona, Italy aut Rugiu Carlo Divisione Nefrologia, Ospedale Civile Maggiore, I-37126, Verona, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 214-217 0940-5429 29:3-4<214 1992 29 592 https://doi.org/10.1007/BF00573490 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573490 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maschio Giuseppe Divisione Nefrologia, Ospedale Civile Maggiore, I-37126, Verona, Italy aut NATIONALLICENCE 700 1- Oldrizzi Lamberto Divisione Nefrologia, Ospedale Civile Maggiore, I-37126, Verona, Italy aut NATIONALLICENCE 700 1- Rugiu Carlo Divisione Nefrologia, Ospedale Civile Maggiore, I-37126, Verona, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 214-217 0940-5429 29:3-4<214 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer