caa a22 4500 469128410 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573501 doi (NATIONALLICENCE)springer-10.1007/BF00573501 Mechanisms of glucose-induced extracellular matrix overproduction by cultured vascular cells [Elektronische Daten] [Flavia Pricci, Giuseppe Pugliese, Francesco Pugliese, Paolo Menè, Domenico Andreani, Gianna Galli, Alessandro Casini, Carlo Rotella, Umberto di Mario] Mesangial expansion, the characteristic anatomical lesion of diabetic glomerulosclerosis, is linked predominantly to accumulation of extracellular matrix, due to either increased production or reduced degradation. Although increased matrix synthesis and/or transcription have been demonstrated in vitro in vascular cells (endothelial cells, pericytes and mesangial cells) exposed to elevated glucose concentrations, the mechanisms of high glucose-induced matrix overproduction are still unclear. Several metabolic and biochemical alterations associated with hyperglycaemia have been implicated in the pathogenesis of these changes. A growing body of experimental evidence suggests that non-enzymatic glycosylation of circulating and matrix proteins with formation of advanced glycosylation end-products, diacylglycerol accumulation and associated protein kinase C activation, or glucose per se, possibly via increased osmolarity, may mediate glucose-induced extracellular matrix overproduction. Springer-Verlag, 1992 Extracellular matrix nationallicence cell culture nationallicence Mesangium nationallicence Diabetic glomerulosclerosis nationallicence Pricci Flavia Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut Pugliese Giuseppe Dipartimento di Medicina Sperimentale, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut Pugliese Francesco Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut Menè Paolo Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut Andreani Domenico Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut Galli Gianna Dipartimento di Fisiopatologia Clinica, Clinica Medica III, University of Florence, Florence, Italy aut Casini Alessandro Dipartimento di Fisiopatologia Clinica, Clinica Medica III, University of Florence, Florence, Italy aut Rotella Carlo Dipartimento di Fisiopatologia Clinica, Clinica Medica III, University of Florence, Florence, Italy aut di Mario Umberto Dipartimento di Medicina Sperimentale e Clinica, University of Reggio Calabria, Catanzaro, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 264-267 0940-5429 29:3-4<264 1992 29 592 https://doi.org/10.1007/BF00573501 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573501 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pricci Flavia Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut NATIONALLICENCE 700 1- Pugliese Giuseppe Dipartimento di Medicina Sperimentale, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut NATIONALLICENCE 700 1- Pugliese Francesco Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut NATIONALLICENCE 700 1- Menè Paolo Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut NATIONALLICENCE 700 1- Andreani Domenico Clinica Medica II, "La Sapienza” University, viale Regina Elena 324, I-00161, Rome, Italy aut NATIONALLICENCE 700 1- Galli Gianna Dipartimento di Fisiopatologia Clinica, Clinica Medica III, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Casini Alessandro Dipartimento di Fisiopatologia Clinica, Clinica Medica III, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Rotella Carlo Dipartimento di Fisiopatologia Clinica, Clinica Medica III, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- di Mario Umberto Dipartimento di Medicina Sperimentale e Clinica, University of Reggio Calabria, Catanzaro, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 264-267 0940-5429 29:3-4<264 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer