caa a22 4500 469128429 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573483 doi (NATIONALLICENCE)springer-10.1007/BF00573483 Renal function in primary hypertension [Elektronische Daten] [C. Barlassina, D. Cusi, P. Bollini, C. Robba, G. Bianchi] Studies of kidney cross-transplantation in the Milan hypertensive strain of rats (MHS) and in its control strain (MNS) have demonstrated that the kidney has a causal role in the development of hypertension in this animal model. The same result was obtained in two other strains of rats with genetic hypertension. Patients receiving a kidney from a donor with hypertensive parents require more antihypertensive therapy than recipients of a kidney from a donor with a normotensive family. When MHS rats and a subset of patients with primary hypertension were compared with their appropriate controls, similar changes in kidney function and Na−K−Cl cotransport were observed. Offspring of hypertensive parents exhibit altered kidney function compared with their controls. Na−K−Cl co-transport in MHS rats is genetically determined and genetically associated with hypertension. In MHS rats the increase in Na−K−Cl co-transport seems to be linked to a cytoskeletal protein, adducin. In conclusion, a consistent sequence of events from a protein abnormality to cell and renal dysfunction may be proposed as being responsible for hypertension. Springer-Verlag, 1992 Erythrocyte nationallicence Genetics nationallicence Renal function nationallicence Sodium transport systems nationallicence Barlassina C. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut Cusi D. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut Bollini P. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut Robba C. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut Bianchi G. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 173-177 0940-5429 29:3-4<173 1992 29 592 https://doi.org/10.1007/BF00573483 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573483 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barlassina C. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut NATIONALLICENCE 700 1- Cusi D. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut NATIONALLICENCE 700 1- Bollini P. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut NATIONALLICENCE 700 1- Robba C. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut NATIONALLICENCE 700 1- Bianchi G. Division of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, University of Milan, via Olgettina 60, I-20132, Milan, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 173-177 0940-5429 29:3-4<173 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer