caa a22 4500 469128453 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573492 doi (NATIONALLICENCE)springer-10.1007/BF00573492 The concomitants of elevated erythrocyte sodium - lithium countertransport activity in diabetic nephropathy: a critical assessment [Elektronische Daten] [R. Mangili, D. Gabellini, G. Pozza] Elevated erythrocyte sodium-lithium countertransport activity is an intermediate phenotype of essential hypertension among Caucasians, and may also associate with kidney disease in type 1 (insulin-dependent) diabetes mellitus. Evidence supporting the hypothesis that an inherited predisposition to essential hypertension may thus partly identify with the genetic background of susceptibility to diabetic nephropathy is, however, controversial. This review discusses the possible points of controversy, with emphasis upon the need to standardize the manifest heterogeneity in the current techniques of measurement, as well as upon the clinical concomitants and interpretation of elevated sodium-lithium countertransport activity in type 1 diabetes mellitus. Large family studies may be required in order to single out the independent contributions of genes and environment to sodium-lithium countertransport activity in type 1 diabetes mellitus. However, the original hypothesis that genes underlying elevated sodium-lithium countertransport in essential hypertension and in diabetic nephropathy may also reflect in part a predisposition to diabetic kidney disease cannot be rejected on the basis of current evidence. Springer-Verlag, 1992 Diabetic nephropathy nationallicence Hypertension nationallicence Microalbuminuria nationallicence Na+/Li+ countertransport nationallicence Type 1 diabetes mellitus nationallicence Mangili R. Department of Clinical Medicine, University of Milan, Scientific Institute San Raffaele, Milan, Italy aut Gabellini D. Department of Clinical Medicine, University of Milan, Scientific Institute San Raffaele, Milan, Italy aut Pozza G. Divisione Medicina I, Istituto Scientifico San Raffaele, Via Olgettina 60, I-20132, Milano, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 221-226 0940-5429 29:3-4<221 1992 29 592 https://doi.org/10.1007/BF00573492 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573492 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mangili R. Department of Clinical Medicine, University of Milan, Scientific Institute San Raffaele, Milan, Italy aut NATIONALLICENCE 700 1- Gabellini D. Department of Clinical Medicine, University of Milan, Scientific Institute San Raffaele, Milan, Italy aut NATIONALLICENCE 700 1- Pozza G. Divisione Medicina I, Istituto Scientifico San Raffaele, Via Olgettina 60, I-20132, Milano, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 221-226 0940-5429 29:3-4<221 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer