caa a22 4500 46912847X CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573481 doi (NATIONALLICENCE)springer-10.1007/BF00573481 Prevalence of hypertension and microalbuminuria in adult type 1 (insulin-dependent) diabetic patients without renal failure in Italy. I. Validation of screening techniques to detect microalbuminuria [Elektronische Daten] The Italian Microalbuminuria Study Group [R. Mangili, G. Deferrari, U. Di Mario, O. Giampietro, R. Navalesi, R. Nosadini, G. Rigamonti, G. Crepaldi] The prevalence of microalbuminuria and arterial hypertension among type 1 (insulin-dependent) diabetic patients is poorly known in Italy. In the preliminary phase of a large outpatient screening programme, we addressed the possibility of using non-time urine samples to predit the chance of detecting albumin excretion rate (AER) in the range of microalbuminuria. We therefore measured urinary albumin and creatinine concentration in timed overnight collections from 641 type 1 diabetic patients with serum creatinine levels lower than 133 μmol/l. AER was strongly and comparably predicted both by urinary albumin concentration (UAlb;r 2=0.754) and by the urinary albumin to creatinine concentration ratio (A/C;r 2=0.773). After exploring several independent cut-off levels for UAlb and A/C, AER in the range 20-200 μg/min (n=91) was found to be predicted with 90% sensitivity and specificity either by UAlb≧20 mg/l or by A/C≧2.0 mg/mmol. UAlb was negatively associated with diuresis, and false negative outcomes were explained by polyuria when screening by this variable. A/C was positively associated with female gender among normoalbuminuric patients, in line with the lower urinary excretion of creatinine in women (7.2±0.25 vs 10.2±0.35 μmol/min,P<0.00001). A significant excess of false positive outcomes in women compared with men was found when screening by any A/C cut-off level equal to or less than 2.5 mg/mmol. Simplified screening techniques seem to remain, however, a practicable option for the detection of microalbuminuria both in epidemiology and in clinical practice. Springer-Verlag, 1992 Diabetic nephropathy nationallicence Microalbuminuria nationallicence Type 1 (insulin0dependent) diabetes mellitus nationallicence Mangili R. Department of Clinical Medicine, Scientific Institute San Raffaele, University of Milan, Milan, Italy aut Deferrari G. Department of Internal Medicine, University of Genoa, Genoa, Italy aut Di Mario U. Department of Endocrinology and Metabolic Diseases, Policlinico Umberto I, University "La Sapienza”, Rome, Italy aut Giampietro O. Department of Clinical Medicine, Ospedale S. Chiara, University of Pisa, Pisa, Italy aut Navalesi R. Department of Clinical Medicine, Ospedale S. Chiara, University of Pisa, Pisa, Italy aut Nosadini R. Institute of Internal Medicine, Policlinico Universitario, University of Padua, Paudua, Italy aut Rigamonti G. Medical Department, ICI Pharmaceuticals, Milan, Italy aut Crepaldi G. Institute of Internal Medicine, Policlinico Universitario, University of Padua, Paudua, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 156-166 0940-5429 29:3-4<156 1992 29 592 https://doi.org/10.1007/BF00573481 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573481 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mangili R. Department of Clinical Medicine, Scientific Institute San Raffaele, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Deferrari G. Department of Internal Medicine, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- Di Mario U. Department of Endocrinology and Metabolic Diseases, Policlinico Umberto I, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Giampietro O. Department of Clinical Medicine, Ospedale S. Chiara, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Navalesi R. Department of Clinical Medicine, Ospedale S. Chiara, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Nosadini R. Institute of Internal Medicine, Policlinico Universitario, University of Padua, Paudua, Italy aut NATIONALLICENCE 700 1- Rigamonti G. Medical Department, ICI Pharmaceuticals, Milan, Italy aut NATIONALLICENCE 700 1- Crepaldi G. Institute of Internal Medicine, Policlinico Universitario, University of Padua, Paudua, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 156-166 0940-5429 29:3-4<156 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer