caa a22 4500 469128518 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573491 doi (NATIONALLICENCE)springer-10.1007/BF00573491 Prostaglandins and the kidney in diabetes [Elektronische Daten] [F. Pugliese, G. Cinotti, P. Menè] The kidney is an active site of prostaglandin synthesis. These autacoids can influence renal haemodynamics, glomerular ultrafiltration coefficient, mesangial cell proliferation and matrix expansion. Due to these features, prostaglandins may contribute to virtually all the functional and structural alterations which characterize the different phases of diabetic nephropathy. Indeed, most of the experimental as well as clinical studies to date agree that renal hyperfiltration of early diabetes is partially dependent upon enhanced renal production of vasodilatory prostaglandins. By contrast, in long-term diabetes the reduced renal synthesis of prostaglandins and increased production of intrarenal thromboxane, be the latter derived from native glomerular cells or from infiltrating platelets or monocytes, would appear to contribute to the decline in glomerular filtration rate, glomerular basement membrane alterations and proteinuria. Springer-Verlag, 1992 Prostaglandins nationallicence Thromboxane nationallicence Diabetes nationallicence Diabetic nephropathy nationallicence Hyperfiltration nationallicence Eicosanoids nationallicence Pugliese F. Cattedra di Nefrologia, University of Rome "La Sapienza”, Rome, Italy aut Cinotti G. Cattedra di Nefrologia, University of Rome "La Sapienza”, Rome, Italy aut Menè P. Cattedra di Nefrologia, University of Rome "La Sapienza”, Rome, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 218-220 0940-5429 29:3-4<218 1992 29 592 https://doi.org/10.1007/BF00573491 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573491 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pugliese F. Cattedra di Nefrologia, University of Rome "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Cinotti G. Cattedra di Nefrologia, University of Rome "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Menè P. Cattedra di Nefrologia, University of Rome "La Sapienza”, Rome, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 218-220 0940-5429 29:3-4<218 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer