caa a22 4500 469128542 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573493 doi (NATIONALLICENCE)springer-10.1007/BF00573493 Mesangial cells in diabetes [Elektronische Daten] [P. Mené, G. Cinotti, F. Pugliese] The glomerular mesangium is the site of prominent structural lesions in diabetic nephropathy, including excess deposition of extracellular matrix in a focal, nodular pattern. Increased single-nephron blood flow and filtration are early signs of glomerular involvement in diabetes, and may initiate or contribute to mesangial damage. Vasodilatation results from arteriolar insensitivity to vasoconstrictors. In turn, this may reflect primary metabolic defects of glomerular smooth muscle, including the afferent arteriole and mesangial cells themselves. Parallel alterations in the glomerular basement membrane and related structures, such as mesangial matrix, are likely to result from glycosylation of intrinsic proteins, or accumulation of advanced glycosylation end-products. Structural and haemodynamic changes account for (micro)-albuminuria, with additional possible overloading of the measangium. Mesangial proliferative changes eventually ensue, with excess matrix deposition and progressive fibrosis. Recent evidence that long-standing hyperglycaemia modifies mesangial metabolism, sensitivity to vasoconstrictors and matrix biosynthesis in vitro is reviewed here, in the light of its potential implications for experimental and human diabetic nephropathy. Springer-Verlag, 1992 Cytosolic Ca2+ nationallicence Diabetes nationallicence Glycosylation nationallicence Hyperglycaemia nationallicence Mesangium nationallicence Phosphoinositides nationallicence Mené P. Cattedra di Nefrologia, University "La Sapienza”, Rome, Italy aut Cinotti G. Cattedra di Nefrologia, University "La Sapienza”, Rome, Italy aut Pugliese F. Cattedra di Nefrologia, University "La Sapienza”, Rome, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 227-230 0940-5429 29:3-4<227 1992 29 592 https://doi.org/10.1007/BF00573493 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573493 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mené P. Cattedra di Nefrologia, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Cinotti G. Cattedra di Nefrologia, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Pugliese F. Cattedra di Nefrologia, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 227-230 0940-5429 29:3-4<227 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer