caa a22 4500 469128569 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573477 doi (NATIONALLICENCE)springer-10.1007/BF00573477 Advanced Maillard reaction products as markers for tissue damage in diabetes and uraemia: relevance to diabetic nephropathy [Elektronische Daten] [Vincent Monnier, David Sell, Satoshi Miyata, Ramanakoppa Nagaraj, Patrizio Odetti, Annuziata Lapolla] Recent work has led to the structural elucidation of three compounds of the advanced Maillard reaction-pyrraline, pentosidine and carboxymethyllysine-which can serve as markers for in vivo studies. Pyrraline is a glucose-derived compound, the presence of which was detected with a monoclonal antibody in elevated amounts in the plasma of diabetic individuals and rodents and in histological sections of renal tissue, especially in sclerosed glomerular and arteriolar regions. The immediate precursor of pyrraline is 3-deoxyglucosone (3-DG), a product formed through degradation of glycated proteins. 3-DG is present in elevated levels in plasma and urine from diabetic humans. Pentosidine is a pentose-derived protein crosslink, which forms from glycated proteins in the presence of oxygen. Pentosidine increases ubiquitously in aging tissues, and at an accelerated rate in diabetes and especially in uraemia. Skin pentosidine levels correlate with the severity of diabetic complications in type I (insulin-dependent) diabetes. Its levels, like those of carboxymethyllysine, an Amadori fragmentation and oxidation product, are not reversible upon tight control of diabetes over a 4-month period. Assuming these advanced products reflect cumulative glycaemia over several years, it would appear that there is a correlation between the severity of complications and total exposure to glucose. Springer-Verlag, 1992 Ascorbate nationallicence Collagen nationallicence Diabetic complications nationallicence Glycation nationallicence Pentosidine nationallicence Retinopathy nationallicence Monnier Vincent Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut Sell David Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut Miyata Satoshi Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut Nagaraj Ramanakoppa Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut Odetti Patrizio Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut Lapolla Annuziata Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 130-135 0940-5429 29:3-4<130 1992 29 592 https://doi.org/10.1007/BF00573477 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573477 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Monnier Vincent Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Sell David Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Miyata Satoshi Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Nagaraj Ramanakoppa Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Odetti Patrizio Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Lapolla Annuziata Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, 2085 Adalbert Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 130-135 0940-5429 29:3-4<130 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer