caa a22 4500 469128607 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573475 doi (NATIONALLICENCE)springer-10.1007/BF00573475 Indices of renal structure and function in patients with type 1 diabetes mellitus [Elektronische Daten] [M. Steffes, P. Fioretto, S. Mauer] The evaluation of renal biopsies from diabetic patients rests upon measurements of many structures in glomeruli, the tubules and the interstitium. These individual values can also be expressed as an index of renal structure. To assess the validity of the individual values versus a published index of renal structure, we evaluated glomerular basement membrane width, mesangial volume fraction, other measures of glomerular structure, and percentage glomerulosclerosis in type 1 diabetic subjects with renal function ranging from normal to marked albuminuria, hypertension, and a falling glomerular filtration rate. For all measured structural parameters and for the index, all groups of diabetic patients, even those who had completely normal renal function, had values different from non-diabetic subjects (P<0.001). Furthermore, there was an excellent correlation between the structural index and a similar functional index (r=0.77). Springer-Verlag, 1992 Diabetes nationallicence Glomerulus nationallicence Mesangium nationallicence Nephropathy nationallicence Steffes M. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA aut Fioretto P. Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA aut Mauer S. Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 119-122 0940-5429 29:3-4<119 1992 29 592 https://doi.org/10.1007/BF00573475 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steffes M. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Fioretto P. Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Mauer S. Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 119-122 0940-5429 29:3-4<119 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer