caa a22 4500 469128615 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573485 doi (NATIONALLICENCE)springer-10.1007/BF00573485 Cardiovascular remodelling and red blood cell Li+/Na+ countertransport in patients with type 1 diabetes and essential hypertension [Elektronische Daten] [Andrea Semplicini, Cinzia Simonella, Roberto Valle, Luca Serena] Patients with type 1 (insulin-dependent) diabetes may develop a specific cardiac disease characterized by functional and structural abnormalities. The pathogenesis of the cardiac disease is poorly understood but cardiac and renal complications may coexist. Patients with overt diabetic nephropathy have increased red cell Li+/Na+ countertransport (CT), which reflects abnormal kinetic properties of the red cell membrane Na+/H+ exchange. Since the activation of Na+/H+ exchange has a key role in cell proliferation and cell growth, as well as in the regulation of cell sodium and cell pH and in the renal reabsorption of Na+ and bicarbonate, we have looked for relationships between red cell Li+/Na+ CT, Na+/H+ exchange and cardiovascular remodeling in patients with type 1 diabetes, essential hypertension and idiopathic familiar cardiomyopathy. In type 1 diabetes the maximal velocity of Li+/Na+ CT is positively correlated with interventricular septum thickness and the left ventricular wall to lumen ratio. Similar results were obtained in patients with essential hypertension. In these patients an increased Li+/Na+ CT is also associated with severe and drug-resistant hypertension and with significant vascular remodelling, estimated by the minimal post-ischaemic vascular resistance in the calf. Finally, Li+/Na+ CT is negatively correlated with diastolic relaxation of the left ventricle in familiar hypertrophic cardiomyopathy. From these data it appears that widespread abnormal kinetic properties of Na+/H+ exchange, estimated by increased red cell Li+/Na+ CT, may have epistatic effects on the pathogenesis of cardiac complications of type 1 diabetes and essential hypertension. Springer-Verlag, 1992 Essential hypertension nationallicence Left ventricular hypertrophy-Li+/Na+ countertransport-Na+/H+ exchange nationallicence Type 1 (insulin-dependent) diabetes nationallicence Semplicini Andrea Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut Simonella Cinzia Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut Valle Roberto Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut Serena Luca Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 182-185 0940-5429 29:3-4<182 1992 29 592 https://doi.org/10.1007/BF00573485 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573485 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Semplicini Andrea Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut NATIONALLICENCE 700 1- Simonella Cinzia Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut NATIONALLICENCE 700 1- Valle Roberto Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut NATIONALLICENCE 700 1- Serena Luca Clinica Medica I, Policlinico Universitario, via Giustiniani 2, I-35126, Padua, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 182-185 0940-5429 29:3-4<182 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer