caa a22 4500 469128666 CHVBK 20180323133157.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00572828 doi (NATIONALLICENCE)springer-10.1007/BF00572828 Familial insulinoma: description of two cases [Elektronische Daten] [M. Maioli, M. Ciccarese, A. Pacifico, G. Tonolo, A. Ganau, S. Cossu, F. Tanda, G. Realdi] We describe cases of isolated functioning insulinoma occurring in two members of the same family (father and daughter). The father had a first encapsulated insulinoma diagnosed at 14 years of age and at the age of 33 years he was operated on for a second insulinoma infiltrating the exocrine pancreas with lymph node metastases. The daughter was operated on for an encapsulated insulinoma in the tail of the pancreas when she was 6 years old. No clinical and laboratory signs of other endocrine disturbances have so far been detected in either care or in any other members of the family. Our report suggests the possibility of multiple familial insulinoma, although this is an extremely rare condition. Our data also indicate that insulinomas, even if well controlled by medical treatment, should always be removed by surgery because malignancy cannot be excluded with certainty. Moreover, patients should be closely followed up, as recurrence may develop up to 15 years after surgery. Springer-Verlag, 1992 Hypoglycaemia nationallicence Islet cell adenoma nationallicence Islet cell carcinoma nationallicence Maioli M. Institute of Clinical Medicine, University of Sassari, Italy aut Ciccarese M. Institute of Clinical Medicine, University of Sassari, Italy aut Pacifico A. Institute of Clinical Medicine, University of Sassari, Italy aut Tonolo G. Institute of Clinical Medicine, University of Sassari, Italy aut Ganau A. Institute of Clinical Medicine, University of Sassari, Italy aut Cossu S. Institute of Pathological Anatomy, University of Sassari, Italy aut Tanda F. Institute of Pathological Anatomy, University of Sassari, Italy aut Realdi G. Institute of Clinical Medicine, University of Sassari, Italy aut Acta Diabetologica Springer-Verlag 29/1(1992-03-01), 38-40 0940-5429 29:1<38 1992 29 592 https://doi.org/10.1007/BF00572828 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00572828 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maioli M. Institute of Clinical Medicine, University of Sassari, Italy aut NATIONALLICENCE 700 1- Ciccarese M. Institute of Clinical Medicine, University of Sassari, Italy aut NATIONALLICENCE 700 1- Pacifico A. Institute of Clinical Medicine, University of Sassari, Italy aut NATIONALLICENCE 700 1- Tonolo G. Institute of Clinical Medicine, University of Sassari, Italy aut NATIONALLICENCE 700 1- Ganau A. Institute of Clinical Medicine, University of Sassari, Italy aut NATIONALLICENCE 700 1- Cossu S. Institute of Pathological Anatomy, University of Sassari, Italy aut NATIONALLICENCE 700 1- Tanda F. Institute of Pathological Anatomy, University of Sassari, Italy aut NATIONALLICENCE 700 1- Realdi G. Institute of Clinical Medicine, University of Sassari, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/1(1992-03-01), 38-40 0940-5429 29:1<38 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer