caa a22 4500 469128704 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00572821 doi (NATIONALLICENCE)springer-10.1007/BF00572821 Relationship between plasma leucine concentration and clearance in normal and type 1 diabetic subjects [Elektronische Daten] [P. Tessari, G. Biolo, S. Inchiostro, L. Saggin, A. Piccoli, A. Tiengo] In a series of studies in normal and type 1 diabetic subjects, we analysed the relationship between isotope-calculated leucine clearance and plasma leucine concentration. All studies were performed under euglycaemic conditions. Plasma leucine concentrations were either experimentally decreased by means of insulin infusion, or increased by means of exogenous amino acid infusion in the presence of hyperinsulinaemia. Leucine clearance rates were compared in normal and diabetic subjects at similar plasma insulin levels. The effect of hyperinsulinaemia was examined by measuring clearance rates in normal subjects at comparable leucine levels but different insulin concentrations. Our data show that leucine clearance is inversely related to leucine concentration, and that it is not independently stimulated by hyperinsulinaemia. Type 1 diabetes is not associated with decreased leucine clearance. A general equation relating leucine concentration and clearance is proposed. These data support the view that peripheral leucine utilization is not decreased in type 1 diabetes mellitus. Springer-Verlag, 1992 Leucine clearance nationallicence Leucine concentration nationallicence Hyperinsulinaemia nationallicence Type 1 diabetes mellitus nationallicence Isotopic methods nationallicence Tessari P. Department of Metabolic Diseases, University of Padova, Italy aut Biolo G. Department of Metabolic Diseases, University of Padova, Italy aut Inchiostro S. Department of Metabolic Diseases, University of Padova, Italy aut Saggin L. Fidia Research Laboratories, Abano Terme, Padova, Italy aut Piccoli A. Department of Internal Medicine, University of Padova, Italy aut Tiengo A. Department of Metabolic Diseases, University of Padova, Italy aut Acta Diabetologica Springer-Verlag 29/1(1992-03-01), 6-10 0940-5429 29:1<6 1992 29 592 https://doi.org/10.1007/BF00572821 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00572821 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tessari P. Department of Metabolic Diseases, University of Padova, Italy aut NATIONALLICENCE 700 1- Biolo G. Department of Metabolic Diseases, University of Padova, Italy aut NATIONALLICENCE 700 1- Inchiostro S. Department of Metabolic Diseases, University of Padova, Italy aut NATIONALLICENCE 700 1- Saggin L. Fidia Research Laboratories, Abano Terme, Padova, Italy aut NATIONALLICENCE 700 1- Piccoli A. Department of Internal Medicine, University of Padova, Italy aut NATIONALLICENCE 700 1- Tiengo A. Department of Metabolic Diseases, University of Padova, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/1(1992-03-01), 6-10 0940-5429 29:1<6 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer