caa a22 4500 469128720 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00572827 doi (NATIONALLICENCE)springer-10.1007/BF00572827 Effects of hyperglycaemia on visual evoked potentials in insulin-dependent diabetic patients [Elektronische Daten] [V. Martinelli, P. Piatti, M. Filippi, M. Pacchioni, M. Pastore, N. Canal, G. Comi] Multimodality evoked potentials frequently reveal subclinical involvement of the central nervous system in patients with insulin-dependent diabetes mellitus. We devised this study to evaluate the possible effects of acute hyperglycaemia on visual evoked potential (VEP) parameters in type 1 diabetic patients. A hyperglycaemic clamp (250 mg/dl for 180 min) was performed in ten patients. Monocular pattern reversal VEPs (check size 15′, contrast 50%) were recorded before, and every 30 min after the start of the clamp. Basal VEP latencies and amplitudes were normal bilaterally in nine patients. No significant changes in pattern reversal and flash VEP parameters were observed after the induction or during the clamp period. None of the neurophysiological parameters evaluated during the test was related to the duration of the disease, the basal VEP latency or amplitude or the presence of retinopathy. Our data suggest that the neurophysiological abnormalities detected in insulin-dependent diabetic patients are due to structural involvement of the central nervous pathways and not to functional damage induced by acute short-term hyperglycaemia. Springer-Verlag, 1992 Visual evoked potentials nationallicence Hyperglycaemic clamp nationallicence Central nervous conduction nationallicence Martinelli V. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Piatti P. Department of Internal Medicine, Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Filippi M. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Pacchioni M. Department of Internal Medicine, Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Pastore M. Department of Internal Medicine, Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Canal N. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Comi G. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut Acta Diabetologica Springer-Verlag 29/1(1992-03-01), 34-37 0940-5429 29:1<34 1992 29 592 https://doi.org/10.1007/BF00572827 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00572827 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martinelli V. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Piatti P. Department of Internal Medicine, Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Filippi M. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Pacchioni M. Department of Internal Medicine, Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Pastore M. Department of Internal Medicine, Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Canal N. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Comi G. Department of Neurology Scientific Institute, St. Raphael Hospital, University of Milan, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/1(1992-03-01), 34-37 0940-5429 29:1<34 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer