caa a22 4500 46912878X CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00572548 doi (NATIONALLICENCE)springer-10.1007/BF00572548 Fibrinogen and von Willebrand factor in type II diabetes mellitus [Elektronische Daten] [Isabella Catalano, Giovanni Davi, Francesco Gennaro, Giuseppe Montalto, Giuseppina Marino, Carlo Giammarresi, Antonina Ganci, Anna Calà, Alberto Notarbartolo] A hypercoagulable state may contribute to the formation of early vascular lesions in diabetes. The von Willebrand factor is required for the attachment of platelets to the subendothelium; fibrinogen is required for platelet aggregation. This study was designed to assess in type II diabetic patients plasma levels of fibrinogen and von Willebrand factor to see if these variables are associated with platelet aggregation responses to adenosine diphosphate (ADP). Fibrinogen and the von Willebrand factor were significantly increased in diabetics but only fibrinogen was significantly related to platelet aggregation for ADP. Strict metabolic control does not reduce the increased concentrations of these two proteins. Hyperfibrinogenaemia was related to the presence of macrovascular disease. Therefore measurements of plasma fibrinogen could be added to the cardiovascular risk factor profile of diabetic patients. Intervention studies are also needed to reduce the increased incidence of thrombotic diseases in patients with diabetes mellitus. Springer-Verlag, 1992 Diabetes mellitus nationallicence Fibrinogen nationallicence von Willebrand factor nationallicence Platelet aggregation nationallicence Catalano Isabella Patologia Medica II, Università di Palermo, Palermo, Italy aut Davi Giovanni Ematologia, Università di Chieti, Chieti, Italy aut Gennaro Francesco Patologia Medica II, Università di Palermo, Palermo, Italy aut Montalto Giuseppe Patologia Medica II, Università di Palermo, Palermo, Italy aut Marino Giuseppina Patologia Medica II, Università di Palermo, Palermo, Italy aut Giammarresi Carlo Patologia Medica II, Università di Palermo, Palermo, Italy aut Ganci Antonina Patologia Medica II, Università di Palermo, Palermo, Italy aut Calà Anna Patologia Medica II, Università di Palermo, Palermo, Italy aut Notarbartolo Alberto Patologia Medica II, Università di Palermo, Palermo, Italy aut Acta Diabetologica Springer-Verlag 29/2(1992-06-01), 78-81 0940-5429 29:2<78 1992 29 592 https://doi.org/10.1007/BF00572548 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00572548 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Catalano Isabella Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Davi Giovanni Ematologia, Università di Chieti, Chieti, Italy aut NATIONALLICENCE 700 1- Gennaro Francesco Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Montalto Giuseppe Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Marino Giuseppina Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Giammarresi Carlo Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Ganci Antonina Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Calà Anna Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Notarbartolo Alberto Patologia Medica II, Università di Palermo, Palermo, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/2(1992-06-01), 78-81 0940-5429 29:2<78 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer