caa a22 4500 469128860 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00572549 doi (NATIONALLICENCE)springer-10.1007/BF00572549 Elevated serum angiotensin I converting enzyme activity in type I, insulin-dependent diabetic subjects with persistent microalbuminuria [Elektronische Daten] [M. Hallab, F. Bled, J. Ebran, S. Suraniti, A. Girault, P. Fressinaud, M. Marre] Angiotensin I-converting enzyme (ACE), which is synthesized by vascular endothelial cells, is sometimes elevated in diabetic subjects. To determine whether serum ACE is elevated in subjects at high risk of malignant microangiopathy, serum ACE activity in 34 normotensive, type 1 insulin-dependent diabetic subjects with persistent microalbuminuria (30-300 mg/24 h) was compared with that in 30 normotensive, normoalbuminuric type 1 diabetic subjects of the same age [37±15 (mean ±SD) vs 38±14 years], sex (21 M/13 F vs 15 M/15 F), stage of retinopathy (14 vs 16 nil/11 vs 7 background/6 vs 4 preproliferative/3 vs 3 proliferative) and HbA1c (7.7±1.9 vs 8.2±1.0%). Serum ACE activity of diabetic subjects was also compared with 120 age and sex related healthy controls. Serum ACE activity was higher in subjects with microalbuminuria than in those with normoalbuminuria (406±114 vs 359±97 IU/l;P=0.03), or in controls (307±95 IU/l;P=0.0001). Normoalbuminuric subjects also had higher ACE activity than controls (P=0.02). Serum ACE activity was not related to diabetes duration (r=0.01; NS), HbA1c (r=0.05; NS), or stage of retinopathy in diabetic subjects (r=0.06; NS), while stage of retinopathy was related to age (r=0.42;P=0.003) and to diabetes duration (r=0.74;P=0.0001) in these subjects. Elevated ACE activity occurs in type 1 diabetic subjects, especially in those with microalbuminuria. This may give early indication of lesions in vascular endothelial cells. Springer-Verlag, 1992 Angiotensin I-converting enzyme nationallicence Microalbuminuria nationallicence Type 1 diabetes nationallicence Retinopathy nationallicence Nephropathy nationallicence Hallab M. Service de médecine B, Angers, France aut Bled F. Laboratoire de Biochimie Universitaire, Angers, France aut Ebran J. Service d'Ophtalmologie, Angers, France aut Suraniti S. Service de médecine B, Angers, France aut Girault A. Laboratoire de Biochimie Universitaire, Angers, France aut Fressinaud P. Service de médecine B, Angers, France aut Marre M. Service de médecine B, Angers, France aut Acta Diabetologica Springer-Verlag 29/2(1992-06-01), 82-85 0940-5429 29:2<82 1992 29 592 https://doi.org/10.1007/BF00572549 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00572549 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hallab M. Service de médecine B, Angers, France aut NATIONALLICENCE 700 1- Bled F. Laboratoire de Biochimie Universitaire, Angers, France aut NATIONALLICENCE 700 1- Ebran J. Service d'Ophtalmologie, Angers, France aut NATIONALLICENCE 700 1- Suraniti S. Service de médecine B, Angers, France aut NATIONALLICENCE 700 1- Girault A. Laboratoire de Biochimie Universitaire, Angers, France aut NATIONALLICENCE 700 1- Fressinaud P. Service de médecine B, Angers, France aut NATIONALLICENCE 700 1- Marre M. Service de médecine B, Angers, France aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/2(1992-06-01), 82-85 0940-5429 29:2<82 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer