caa a22 4500 469128879 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00778999 doi (NATIONALLICENCE)springer-10.1007/BF00778999 Insulin resistance and endogenous digoxin-like factor in obese hypertensive patients with glucose intolerance [Elektronische Daten] [G. Andronico, G. Mulé, M. Mangano, G. Piazza, M. Donatelli, G. Cerasola, G. Bompiani] Hypertensive obese subjects with glucose intolerance have hyperinsulinaemia, insulin resistance and intracellular cation imbalance resulting in increased sodium content. The aim of our study was to assess in these patients plasma levels of endogenous digoxin-like factor (EDLF), an inhibitor of the sodium-pump mechanism. We studied 14 hypertensive and 12 normotensive subjects with obesity and glucose intolerance for fasting blood glucose, and plasma insulin, C-peptide and EDLF levels: the two groups were matched for age and BMI and were studied after a 2-week wash-out period from hypotensive drugs. Compared with normotensives, hypertensive subjects had higher plasma insulin levels, a greater immunoreactive insulin/C-peptide ratio, a lower glucose/insulin ratio and higher plasma EDLF levels. Our results confirm that among obese people with glucose intolerance, hypertensives are more hyperinsulinaemic and insulin-resistant than normotensives and indicate that the intracellular cation imbalance in these patients may be attributable, at least in part, to EDLF. Springer-Verlag, 1992 Endogenous digoxin-like factor nationallicence Insulin resistance nationallicence Hypertension nationallicence Obesity nationallicence Andronico G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut Mulé G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut Mangano M. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut Piazza G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut Donatelli M. Chair of Internal Medicine II, University of Palermo, Palermo, Italy aut Cerasola G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut Bompiani G. Chair of Internal Medicine II, University of Palermo, Palermo, Italy aut Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 203-205 0940-5429 28:3-4<203 1992 28 592 https://doi.org/10.1007/BF00778999 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00778999 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andronico G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Mulé G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Mangano M. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Piazza G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Donatelli M. Chair of Internal Medicine II, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Cerasola G. Chair of Internal Medicine I and Hypertension Centre, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Bompiani G. Chair of Internal Medicine II, University of Palermo, Palermo, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 203-205 0940-5429 28:3-4<203 1992 28 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer