caa a22 4500 469128895 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00779002 doi (NATIONALLICENCE)springer-10.1007/BF00779002 A comparative study of antigen expression by skin and pancreas in the prediabetic and diabetic state of the BB rat [Elektronische Daten] [M. Woehrle, K. Blumrich, R. Bretzel, K. Federlin] Type 1, insulin-dependent diabetes mellitus is an autoimmune disease with destruction of beta-cells in islets of Langerhans by activated (antigen-positive) infiltrating mononuclear cells accompanied by serological immune phenomena. The pathological mechanism has not yet been clarified in detail, and some inversion in the proportion of epidermal antigen expression has recently been described in spontaneous diabetes. The BB rat is one of the animal models most closely resembling human type 1 diabetes of autoimmune origin. We compared the class 1 and class II antigen expression in the islets of Langerhans and in the skin of spontaneously diabetic (BBD) and normoglycaemic (BBND) BB rats in the prediabetic, diabetic and non-diabetic states. Class I and class II antigen expression increased significantly in the islets of BBD rats from prediabetes to diabetes and compared with non-diabetic controls. In the same period, the dermal antigen expression (class I and class II) did not decrease and was not lower in BBD than in BBND animals. These results do not support a loss of activated (antigen-positive) dermal cells at the onset of diabetes in the BB rat and do not show a clear correlation with the antigen expression in infiltrated islets of Langerhans. Springer-Verlag, 1992 Autoimmune diabetes nationallicence BB rat nationallicence Antigen expression nationallicence Insulitis nationallicence Skin nationallicence Woehrle M. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut Blumrich K. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut Bretzel R. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut Federlin K. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 215-220 0940-5429 28:3-4<215 1992 28 592 https://doi.org/10.1007/BF00779002 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00779002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Woehrle M. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Blumrich K. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Bretzel R. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Federlin K. Medical Clinic III and Policlinic, University of Giessen, Rodthohl 6, W-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 215-220 0940-5429 28:3-4<215 1992 28 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer