caa a22 4500 469128909 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00779004 doi (NATIONALLICENCE)springer-10.1007/BF00779004 HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease [Elektronische Daten] [E. Bognetti, F. Meschi, C. Malavasi, M. Pastore, A. Sergi, M. Illeni, C. Maffeis, L. Pinelli, G. Chiumello] HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease. Springer-Verlag, 1992 HLA nationallicence Insulin-dependent diabetes mellitus nationallicence Breast feeding nationallicence Childhood nationallicence Bognetti E. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut Meschi F. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut Malavasi C. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut Pastore M. Department of Internal Medicine, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut Sergi A. Department of Internal Medicine, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut Illeni M. Department of Immunohaematology, Istituto Nazionale dei Tumori, Milan, Italy aut Maffeis C. Department of Paediatrics, University of Verona, Verona, Italy aut Pinelli L. Department of Paediatrics, University of Verona, Verona, Italy aut Chiumello G. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 229-232 0940-5429 28:3-4<229 1992 28 592 https://doi.org/10.1007/BF00779004 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00779004 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bognetti E. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Meschi F. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Malavasi C. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Pastore M. Department of Internal Medicine, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Sergi A. Department of Internal Medicine, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Illeni M. Department of Immunohaematology, Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Maffeis C. Department of Paediatrics, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Pinelli L. Department of Paediatrics, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Chiumello G. Department of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan, Milan, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 229-232 0940-5429 28:3-4<229 1992 28 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer