caa a22 4500 469128925 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00779001 doi (NATIONALLICENCE)springer-10.1007/BF00779001 Diabetes-induced alteration of HMGCoA reductase forms in rat livers [Elektronische Daten] [F. Magni, M. Cancellieri, M. Del Puppo, M. Kienle] The effects of streptozotocin-induced diabetes on the various forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoA reductase), phosphorylated/dephosphorylated and thiolic/disulphide, were studied in rat liver. Animals were treated twice with 65 mg/kg intraperitoneally of streptozotocin to induce diabetes and sacrificed after 5 days. The relative amounts of the four possible forms of the enzyme were determined in control and diabetic rats. As determined from the total activity, and in agreement with previous reports, the enzyme protein was significantly decreased in streptozotocin-treated rats. However, the percentage of the active thiolic dephosphorylated form was higher in these animals than in controls, suggesting a response of the liver to the decrease both total and specific activity of HMGCoA reductase. Springer-Verlag, 1992 HMGCoA reductase nationallicence Streptozotocin nationallicence GSH nationallicence Rat liver nationallicence Diabetes nationallicence Magni F. Scientific Institute H. S. Raffaele, Via Olgettina 60, Milan, Italy aut Cancellieri M. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan, Italy aut Del Puppo M. Department of Medical Chemistry and Biochemistry, University of Milan, Via Saldini 50, I-20133, Milan, Italy aut Kienle M. Department of Medical Chemistry and Biochemistry, University of Milan, Via Saldini 50, I-20133, Milan, Italy aut Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 211-214 0940-5429 28:3-4<211 1992 28 592 https://doi.org/10.1007/BF00779001 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00779001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Magni F. Scientific Institute H. S. Raffaele, Via Olgettina 60, Milan, Italy aut NATIONALLICENCE 700 1- Cancellieri M. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan, Italy aut NATIONALLICENCE 700 1- Del Puppo M. Department of Medical Chemistry and Biochemistry, University of Milan, Via Saldini 50, I-20133, Milan, Italy aut NATIONALLICENCE 700 1- Kienle M. Department of Medical Chemistry and Biochemistry, University of Milan, Via Saldini 50, I-20133, Milan, Italy aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 211-214 0940-5429 28:3-4<211 1992 28 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer