caa a22 4500 469128992 CHVBK 20180323133158.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00778998 doi (NATIONALLICENCE)springer-10.1007/BF00778998 Asymptomatic coronary artery disease in diabetes: associated with autonomic neuropaphy? [Elektronische Daten] [M. Koistinen, K. Airaksinen, Heikki Huikuri, Heikki Pirttiaho, Markku Linnaluoto, Markku Ikäheimo, Juha Takkunen] To elucidate the potential association of diabetic autonomic neuropathy with increased prevalence of silent coronary artery disease (CAD), 138 asymptomatic diabetic subjects were screened using exercise ECG. 24-h ambulatory ECG and dynamic thallium scintigraphy. Fourteen patients with exercise-induced myocardial ischaemia and angiographically confirmed CAD (≥50% coronary artery narrowing) were found using this protocol. Their autonomic nervous function was assessed using standard cardiovascular tests and compared with that of 23 consecutive diabetic patients catheterised because of symptomatic CAD (mean New York Heart Association class 3.0). The diabetic patients with symptomatic CAD had more severe coronary atherosclerosis than the diabetic patients with asymptomatic CAD assessed by jeopardy score (P<0.01). The groups did not, however, differ with respect to autonomic function tests. Five patients (22%) with symptomatic CAD and 3 patients (21%) with asymptomatic CAD had definite autonomic dysfunction, i.e. two or more abnormal tests. Thus, our results suggest that the frequency of autonomic neuropathy is not increased in diabetic patients with asymptomatic CAD. The contribution of diabetic autonomic neuropathy to the absence of cardiac pain needs further clinical and pathological studies. Springer-Verlag, 1992 Diabetes mellitus nationallicence Asymptomatic coronary artery disease nationallicence Diabetic neuropathy nationallicence Autonomic nervous function nationallicence Koistinen M. Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Airaksinen K. Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Huikuri Heikki Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Pirttiaho Heikki Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Linnaluoto Markku Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Ikäheimo Markku Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Takkunen Juha Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 199-202 0940-5429 28:3-4<199 1992 28 592 https://doi.org/10.1007/BF00778998 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00778998 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koistinen M. Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 700 1- Airaksinen K. Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 700 1- Huikuri Heikki Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 700 1- Pirttiaho Heikki Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 700 1- Linnaluoto Markku Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 700 1- Ikäheimo Markku Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 700 1- Takkunen Juha Division of Cardiology, Department of Medicine, Oulu University, SF-90220, Oulu, Finland aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 28/3-4(1992-09-01), 199-202 0940-5429 28:3-4<199 1992 28 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer