caa a22 4500 475737849 CHVBK 20180406123451.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s004300000032 doi (NATIONALLICENCE)springer-10.1007/s004300000032 Binding of human lipoproteins (low, very low, high density lipoproteins) to recombinant envelope proteins of hepatitis C virus [Elektronische Daten] [Masyar Monazahian, Serena Kippenberger, Anke Müller, Holger Seitz, Ingo Böhme, Stefanie Grethe, Reiner Thomssen] Heterogeneities in the density of hepatitis C virus (HCV)-RNA-carrying material from human sera (1.03-1.20 g/ml) are partially due to the binding of lipoproteins [low density (LDL), very low density (VLDL), high density (HDL) lipoproteins] and immunoglobulins. In this study we demonstrate the binding of recombinant HCV envelope protein (E1/E2) to human LDL, VLDL and HDL on a molecular basis. The binding of lipoproteins was restricted to the middle part of the E1 gene product (amino acids 222-336) and the C-terminal part of the E2 protein (amino acids 523-809). Lipoproteins did not bind to recombinant HCV core protein. Springer-Verlag Berlin Heidelberg, 2000 Key words Hepatitis C virus nationallicence Lipoprotein nationallicence Low, very low, high density lipoprotein nationallicence Recombinant hepatitis C virus envelope protein nationallicence Binding site nationallicence Monazahian Masyar Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Kippenberger Serena Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Müller Anke Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Seitz Holger Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Böhme Ingo Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Grethe Stefanie Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Thomssen Reiner Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut https://doi.org/10.1007/s004300000032 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004300000032 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Monazahian Masyar Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut NATIONALLICENCE 700 1- Kippenberger Serena Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut NATIONALLICENCE 700 1- Müller Anke Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut NATIONALLICENCE 700 1- Seitz Holger Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut NATIONALLICENCE 700 1- Böhme Ingo Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut NATIONALLICENCE 700 1- Grethe Stefanie Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut NATIONALLICENCE 700 1- Thomssen Reiner Department of Virology, University of Göttingen, Kreuzbergring 57, 37075, Gögottingen, Deutschland aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer