caa a22 4500 475737962 CHVBK 20180406123452.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004300000044 doi (NATIONALLICENCE)springer-10.1007/s004300000044 Genes outside the major histocompatibility complex control resistance and susceptibility to experimental Lyme arthritis [Elektronische Daten] [Charles R. Brown, Steven L. Reiner] The mechanism controlling the development of experimental Lyme arthritis remains poorly understood. Mice with the H-2k haplotype have generally been thought to be more susceptible to Lyme arthritis development than those with the H-2d haplotype. In the present study the role of genes within the major histocompatibility complex (MHC) in determining resistance or susceptibility to the development of experimental Lyme arthritis was investigated. We found that C3H congenic mice were equally susceptible, and DBA congenic mice equally resistant, to arthritis development regardless of their H-2 haplotype (H-2k or H-2d). These results indicate that genes outside the murine MHC are the major determinants of both resistance and susceptibility to the development of experimental Lyme arthritis. Springer-Verlag Berlin Heidelberg, 2000 Key wordsBorrelia burgdorferi nationallicence Lyme borreliosis nationallicence MHC restriction nationallicence Arthritis nationallicence Pathology nationallicence Brown Charles R. Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 924E. 57th Street, R402, Chicago, IL 60637, USA, US aut Reiner Steven L. Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, 414 BRB II, Philadelphia, PA 19104, USA e-mail: sreiner@mail.med.upenn.edu Tel.: +1-215-7465536; Fax: +1-215-7465525, US aut https://doi.org/10.1007/s004300000044 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004300000044 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brown Charles R. Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 924E. 57th Street, R402, Chicago, IL 60637, USA, US aut NATIONALLICENCE 700 1- Reiner Steven L. Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, 414 BRB II, Philadelphia, PA 19104, USA e-mail: sreiner@mail.med.upenn.edu Tel.: +1-215-7465536; Fax: +1-215-7465525, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer