caa a22 4500 475737989 CHVBK 20180406123452.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00008256 doi (NATIONALLICENCE)springer-10.1007/PL00008256 Borna disease virus and schizophrenia in Surinamese immigrants to the Netherlands [Elektronische Daten] [Jean-Paul Selten, Karin van Vliet, Willem Pleyte, Sibylle Herzog, Hans W. Hoek, Anton M. van Loon] Borna disease virus (BDV) has been suggested to play a role in the etiology of schizophrenia. We tested the hypothesis that markers of BDV infection are more frequent in Surinamese immigrants to the Netherlands, diagnosed with schizophrenia, than in Dutch-born healthy subjects. For reasons that are poorly understood there is an increased incidence of schizophrenia in this immigrant group. Blood was obtained from 29 male schizophrenic patients (DSM-IV criteria) and from 26 healthy males. For detection of anti-BDV antibodies an indirect immunofluorescence assay (IFA) was performed. A nested, reverse-transcriptase-PCR, using primers specific for the p24 and p40 BDV genes, was used to determine BDV-RNA in peripheral blood mononuclear cells. Contrary to our expectations, the frequencies of BDV markers in the group of healthy subjects, as determined by IFA and both PCRs, exceeded that in the group of patients. The results do not support an association between markers of BDV infection in blood and schizophrenia. It is unlikely that the high incidence of schizophrenia in Surinamese immigrants is caused by BDV, but the small number of subjects examined do not warrant definitive conclusions. Springer-Verlag Berlin Heidelberg, 2000 Key words Borna disease virus nationallicence Schizophrenia nationallicence Epidemiology nationallicence Etiology nationallicence Migration nationallicence Selten Jean-Paul Department of Psychiatry, University Hospital, P.O. Box 85500, 3508 GA Utrecht, The Netherlands e-mail: j.p.selten@psych.azu.nl Tel.: +31-30-2507473; Fax: +31-30-2505443, NL aut van Vliet Karin Department of Virology, University Hospital, P.O. Box 85500, 3508 GA Utrecht, The Netherlands, NL aut Pleyte Willem Parnassia Psychiatric Centre, Albardastraat 100, 2555 VZ The Hague, The Netherlands, NL aut Herzog Sibylle Institute of Virology, Justus-Liebig Universität, Frankfurterstrasse 107, 35392 Giessen, Germany, DE aut Hoek Hans W. Parnassia Psychiatric Centre, Albardastraat 100, 2555 VZ The Hague, The Netherlands, NL aut van Loon Anton M. Department of Virology, University Hospital, P.O. Box 85500, 3508 GA Utrecht, The Netherlands, NL aut https://doi.org/10.1007/PL00008256 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008256 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Selten Jean-Paul Department of Psychiatry, University Hospital, P.O. Box 85500, 3508 GA Utrecht, The Netherlands e-mail: j.p.selten@psych.azu.nl Tel.: +31-30-2507473; Fax: +31-30-2505443, NL aut NATIONALLICENCE 700 1- van Vliet Karin Department of Virology, University Hospital, P.O. Box 85500, 3508 GA Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Pleyte Willem Parnassia Psychiatric Centre, Albardastraat 100, 2555 VZ The Hague, The Netherlands, NL aut NATIONALLICENCE 700 1- Herzog Sibylle Institute of Virology, Justus-Liebig Universität, Frankfurterstrasse 107, 35392 Giessen, Germany, DE aut NATIONALLICENCE 700 1- Hoek Hans W. Parnassia Psychiatric Centre, Albardastraat 100, 2555 VZ The Hague, The Netherlands, NL aut NATIONALLICENCE 700 1- van Loon Anton M. Department of Virology, University Hospital, P.O. Box 85500, 3508 GA Utrecht, The Netherlands, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer