caa a22 4500 475738829 CHVBK 20180406123453.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1005503502992 doi (NATIONALLICENCE)springer-10.1023/A:1005503502992 DNA Repair Capacity in Healthy Medical Students During and After Exam Stress [Elektronische Daten] [Lorenzo Cohen, Gailen Marshall Jr., Lie Cheng, Sandeep Agarwal, Qingyi Wei] There has been extensive research into the effects of stress on immune function but little on the effects of stress on DNA repair capacity (DRC), a process central to maintaining a normal cell cycle. Defective DRC is one of the factors responsible for carcinogenesis. In the present study we assessed DRC in healthy medical students during times of high and low stress. Sixteen medical students were evaluated during the third day of a 5-day exam period and then again 3 weeks later, after vacation. At both time points, participants underwent a brief physical examination, had venous blood drawn, and completed questionnaires to identify subjective stress levels. The DRC was assessed by the host-cell reaction assay, which measures nucleotide excision repair capacity. Participants reported significantly higher levels of subjective stress during the exam period than after vacation. DRC was also significantly higher during the exam period than after vacation, suggesting a positive association between subject stress levels and DRC. The results are discussed in relation to previous findings and implications for cancer research. Plenum Publishing Corporation, 2000 stress nationallicence DNA repair nationallicence depression nationallicence carcinogenesis nationallicence cancer nationallicence Cohen Lorenzo Department of Behavioral Science, The University of Texas M. D. Anderson Cancer Center, USA aut Marshall Jr. Gailen Division of Allergy & Clinical Immunology, Department of Internal Medicine, The University of Texas Houston Medical School, 6431 Fannin 4.044 MSB, 77030, Houston, Texas aut Cheng Lie Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, USA aut Agarwal Sandeep Division of Allergy & Clinical Immunology, Department of Internal Medicine, The University of Texas—Houston Medical School, USA aut Wei Qingyi Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, USA aut Journal of Behavioral Medicine Kluwer Academic Publishers-Plenum Publishers 23/6(2000-12-01), 531-544 0160-7715 23:6<531 2000 23 10865 https://doi.org/10.1023/A:1005503502992 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1005503502992 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen Lorenzo Department of Behavioral Science, The University of Texas M. D. Anderson Cancer Center, USA aut NATIONALLICENCE 700 1- Marshall Jr Gailen Division of Allergy & Clinical Immunology, Department of Internal Medicine, The University of Texas Houston Medical School, 6431 Fannin 4.044 MSB, 77030, Houston, Texas aut NATIONALLICENCE 700 1- Cheng Lie Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, USA aut NATIONALLICENCE 700 1- Agarwal Sandeep Division of Allergy & Clinical Immunology, Department of Internal Medicine, The University of Texas—Houston Medical School, USA aut NATIONALLICENCE 700 1- Wei Qingyi Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, USA aut NATIONALLICENCE 773 0- Journal of Behavioral Medicine Kluwer Academic Publishers-Plenum Publishers 23/6(2000-12-01), 531-544 0160-7715 23:6<531 2000 23 10865 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer