caa a22 4500 475739728 CHVBK 20180406123456.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1005113900068 doi (NATIONALLICENCE)springer-10.1023/A:1005113900068 Rutter Michael Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK aut Genetic Studies of Autism: From the 1970s into the Millennium [Elektronische Daten] [Michael Rutter] Reviewers in the 1960s and early 1970s were skeptical about any substantial role for genetic factors in the etiology of autism. A realization that the 2% rate of autism in siblings (as estimated at that time) was far above the general population base rate, and that this suggested a possible high genetic liability, led to the first small-scale twin study of autism. The replicated evidence from both twin and family studies undertaken in the 1970s and 1980s indicated both strong genetic influences and the likelihood that they applied to a phenotype that was much broader than the traditional diagnostic category of autism. Medical and chromosomal findings also indicated genetic heterogeneity. Advances in molecular genetics led to genome-wide scans of affected relative pair samples with a positive log of the odds to base 10 score for a location on chromosome 7. The major remaining research challenges and the likely clinical benefits that should derive from genetic research are considered in relation to both current knowledge and that anticipated to emerge from research over the next decade. Plenum Publishing Corporation, 2000 Autism nationallicence quantitative genetics nationallicence molecular genetics nationallicence functional genomics nationallicence clinical practice nationallicence Journal of Abnormal Child Psychology Kluwer Academic Publishers-Plenum Publishers 28/1(2000-02-01), 3-14 0091-0627 28:1<3 2000 28 10802 https://doi.org/10.1023/A:1005113900068 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1005113900068 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rutter Michael Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK aut NATIONALLICENCE 773 0- Journal of Abnormal Child Psychology Kluwer Academic Publishers-Plenum Publishers 28/1(2000-02-01), 3-14 0091-0627 28:1<3 2000 28 10802 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer