caa a22 4500 475742370 CHVBK 20180406123503.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s002400050003 doi (NATIONALLICENCE)springer-10.1007/s002400050003 Impaired endothelium-dependent and neurogenic relaxation of corpus cavernosum from diabetic rats: improvement with L -arginine [Elektronische Daten] [S. Gür, B. Öztürk, S. T. Karahan] This study describes the relaxant response to acetylcholine, electrical field stimulation and sodium nitroprusside after contraction by phenylephrine (10−5 M) in corpus cavernosum from control and diabetic rats. The response to acetylcholine (10−9-10−3 M) and electrical field stimulation (0.5-64 Hz) is decreased and can be restored by the addition of nitric oxide synthatase substrate, l-arginine(10−5 M). The response to sodium nitroprusside is not changed in diabetic rats compared to control rats. NADPH-diaphorase staining was enhanced in a diabetic preparation compared to control preparations. The findings suggest a role for the depletion of l-arginine in diabetes mellitus. The enhanced NADPH-diaphorase staining may be due to a deficiency of NOS substrate l-arginine in the endothelium and nerves of diabetic tissues. Springer-Verlag Berlin Heidelberg, 2000 Key words Acetylcholine nationallicence Diabetes mellitus nationallicence L-arginine nationallicence Corpora cavernosa nationallicence Gür S. Ankara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı 06100 Tandoğan, Ankara, Turkey e-mail: sgur@pharmacy.ankara.edu.tr Tel.: +90 312-2126805/253, Fax: +90 312-2131081, TR aut Öztürk B. Department of Urology, Numune Hospital, Ankara, Turkey, TR aut Karahan S. T. Department of Anatomy, Faculty of Medicine, Ankara University, Ankara, Turkey, TR aut https://doi.org/10.1007/s002400050003 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400050003 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gür S. Ankara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı 06100 Tandoğan, Ankara, Turkey e-mail: sgur@pharmacy.ankara.edu.tr Tel.: +90 312-2126805/253, Fax: +90 312-2131081, TR aut NATIONALLICENCE 700 1- Öztürk B. Department of Urology, Numune Hospital, Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Karahan S. T. Department of Anatomy, Faculty of Medicine, Ankara University, Ankara, Turkey, TR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer