caa a22 4500 475742435 CHVBK 20180406123503.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s002400050007 doi (NATIONALLICENCE)springer-10.1007/s002400050007 Effect of aging on bladder function and the response to outlet obstruction in female rats [Elektronische Daten] [A.D. Kohan, M. Danziger, E.D. Vaughan Jr, D. Felsen] Bladder dysfunction in the aging population is a significant problem. However the concomitant presence of other diseases in many patients can make it difficult to distinguish between changes in bladder function and other influences. The present study was designed to study, in aging rats, bladder function and the effect of partial bladder outlet obstruction (BOO) on bladder function. Cystometrics were performed in awake, female Fischer 344 rats of four age groups (6, 12, 18 and 24 months) following subcutaneous implantation of a mediport catheter. Cystometric evaluations were carried out in control rats or those subject to three weeks of BOO. Bladder compliance significantly decreased with aging, which reflected an increase in threshold pressure without changes in bladder capacity. Partial BOO caused development of severe bladder instability. Following BOO, bladder capacity and compliance were significantly increased in all age groups. Threshold pressure was lower in obstructed animals, except for 6-month rats. Younger animals were able to generate a higher contraction pressure to compensate for the BOO, whereas older animals did not. Using an awake model of cystometric measurement, we have demonstrated that aging, by itself can affect bladder function. Furthermore, aged animals respond differently to BOO than younger animals. These results demonstrate that both aging and disease can contribute to bladder dysfunction, and suggest that treatment of bladder dysfunction may require a combination of therapies targeted to multiple etiologies. Springer-Verlag Berlin Heidelberg, 2000 Key words Bladder nationallicence Rat nationallicence Aging nationallicence Obstruction nationallicence Cystometrics nationallicence Kohan A.D. The James Buchanan Brady Foundation, New York-Hospital Cornell Medical Center, Department of Urology, New York, USA, US aut Danziger M. The James Buchanan Brady Foundation, New York-Hospital Cornell Medical Center, Department of Urology, New York, USA, US aut Vaughan Jr E.D. The James Buchanan Brady Foundation, New York-Hospital Cornell Medical Center, Department of Urology, New York, USA, US aut Felsen D. Cornell University Medical College, Department of Urology, Box 94, 1300 York Avenue, New York, N.Y. 10021, USA e-mail: dfelsen@mail.med.cornell.edu Tel.: +1 212-746-5796, Fax: +1 212-746-8153, US aut https://doi.org/10.1007/s002400050007 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400050007 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kohan A.D. The James Buchanan Brady Foundation, New York-Hospital Cornell Medical Center, Department of Urology, New York, USA, US aut NATIONALLICENCE 700 1- Danziger M. The James Buchanan Brady Foundation, New York-Hospital Cornell Medical Center, Department of Urology, New York, USA, US aut NATIONALLICENCE 700 1- Vaughan Jr E.D. The James Buchanan Brady Foundation, New York-Hospital Cornell Medical Center, Department of Urology, New York, USA, US aut NATIONALLICENCE 700 1- Felsen D. Cornell University Medical College, Department of Urology, Box 94, 1300 York Avenue, New York, N.Y. 10021, USA e-mail: dfelsen@mail.med.cornell.edu Tel.: +1 212-746-5796, Fax: +1 212-746-8153, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer