caa a22 4500 475742443 CHVBK 20180406123503.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s002400050010 doi (NATIONALLICENCE)springer-10.1007/s002400050010 Clinical, histopathological and flow-cytometric properties of incidental renal cell carcinomas [Elektronische Daten] [D. Katušin, B. Užarević, M. Petrovečki, M. Mlinac-Lucijanić, M. Marušić, Z. Mareković] Medical records of 63 patients operated on for renal cell carcinoma (RCC) between 1986 and 1996 in the Karlovac General Hospital were studied retrospectively. In 23 (36.5%) patients, the tumor was incidentally detected. The median patient age was 62 in the incidental group and 64 years in the symptomatic group (P > 0.05). Ultrasonography was the leading technique for incidental detection of RCC. The median tumor diameter was 6 cm in the incidental group and 9 cm in the symptomatic group (P < 0.001). Incidental carcinomas had a lower stage (P = 0.022) and a lower nuclear grade (P < 0.001) than the symptomatic ones. The incidental cases were associated with a more favorable ploidy status (P = 0.027) and a lower proliferative activity (P = 0.005). The 5-year survival rate was significantly higher in incidental (81.4%) than in symptomatic cases (44.3%) (P = 0.020). Univariate analysis showed that tumor stage, ploidy status, and proliferative activity were good prognostic parameters, while patient age, tumor size, and nuclear grade were not. Tumor stage was the only independent prognostic parameter in multivariate analysis. In conclusion, the incidentally detected RCC show more favorable clinical, histopathological, and flow-cytometric characteristics and their prognosis is significantly better than in symptomatic cases. Springer-Verlag Berlin Heidelberg, 2000 Key words Renal cell carcinoma nationallicence Incidental renal tumors nationallicence Flow-cytometry nationallicence Prognostic factors nationallicence Katušin D. Karlovac General Hospital, Department of Urology, Andrije Štampara 3, 47000 Karlovac, Croatia e-mail: davorin.katusin@ka.tel.hr Tel.: 385 47 331 299, Fax: +385 47 336 090, HR aut Užarević B. Department of Clinical Laboratory Diagnosis, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia, HR aut Petrovečki M. Department of Informatics, Rijeka University School of Medicine and Dubrava Clinical Hospital, Zagreb, Croatia, HR aut Mlinac-Lucijanić M. Division of Pathology, Karlovac General Hospital, Karlovac, Croatia, HR aut Marušić M. Department of Clinical Laboratory Diagnosis, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia, HR aut Mareković Z. Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia, HR aut https://doi.org/10.1007/s002400050010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400050010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katušin D. Karlovac General Hospital, Department of Urology, Andrije Štampara 3, 47000 Karlovac, Croatia e-mail: davorin.katusin@ka.tel.hr Tel.: 385 47 331 299, Fax: +385 47 336 090, HR aut NATIONALLICENCE 700 1- Užarević B. Department of Clinical Laboratory Diagnosis, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia, HR aut NATIONALLICENCE 700 1- Petrovečki M. Department of Informatics, Rijeka University School of Medicine and Dubrava Clinical Hospital, Zagreb, Croatia, HR aut NATIONALLICENCE 700 1- Mlinac-Lucijanić M. Division of Pathology, Karlovac General Hospital, Karlovac, Croatia, HR aut NATIONALLICENCE 700 1- Marušić M. Department of Clinical Laboratory Diagnosis, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia, HR aut NATIONALLICENCE 700 1- Mareković Z. Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia, HR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer