caa a22 4500 475742451 CHVBK 20180406123503.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s002400050008 doi (NATIONALLICENCE)springer-10.1007/s002400050008 Effects of ovarian hormones on β-adrenergic receptor-mediated relaxation in the female rabbit bladder [Elektronische Daten] [M. Yono, M. Yoshida, W. Takahashi, A. Inadome, H. Seshita, Y. Miyamoto, S. Ueda] The effects of ovarian hormones on β-adrenergic receptor-mediated responses in female rabbit detrusor smooth muscles were investigated. Ovariectomized mature female New Zealand white rabbits were untreated or treated with estrogen and/or progesterone for 2 weeks. The contractile responses to carbachol and KCl in the detrusor strips were not significantly different in all groups. As compared with dobutamine and GS-332, isoproterenol and procaterol significantly relaxed the detrusor strips derived from all groups on KCl-induced tonic contractions. Combined with estrogen treatment, isoproterenol, procaterol and GS-332 caused a significant increase in this muscle relaxation. Furthermore, estrogen treatment caused a significant increase in relaxation as a result of forskolin and the cyclic AMP (cAMP) production that was induced by isoproterenol, procaterol and GS-332. However, estrogen treatment did not affect the relaxant response to dibutyryl cyclic AMP. Progesterone treatment did not affect β-adrenergic receptor-mediated responses. These results suggest that estrogen treatment causes the increased relaxant responses mediated by β2- and β3-adrenergic receptor subtypes, which may be related to the increased cAMP content in female rabbit detrusor smooth muscles. Springer-Verlag Berlin Heidelberg, 2000 Key words Estrogen nationallicence Progesterone nationallicence β-Adrenergic receptor subtypes nationallicence Rabbit bladder nationallicence Yono M. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Yoshida M. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Takahashi W. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Inadome A. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Seshita H. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Miyamoto Y. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Ueda S. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut https://doi.org/10.1007/s002400050008 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400050008 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yono M. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut NATIONALLICENCE 700 1- Yoshida M. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut NATIONALLICENCE 700 1- Takahashi W. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut NATIONALLICENCE 700 1- Inadome A. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut NATIONALLICENCE 700 1- Seshita H. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut NATIONALLICENCE 700 1- Miyamoto Y. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut NATIONALLICENCE 700 1- Ueda S. Department of Urology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan Tel.: +81 96 373 5240, Fax: +81 96 373 5242, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer