caa a22 4500 475742613 CHVBK 20180406123504.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002409900077 doi (NATIONALLICENCE)springer-10.1007/s002409900077 Aberration of chromosomes 8 and 11 in bladder cancer as detected by fluorescence in situ hybridization [Elektronische Daten] [S. Awata, H. Sakagami, K. Tozawa, S. Sasaki, K. Ueda, K. Kohri] Although a bladder cancer-specific abnormality in chromosomes or genes has not been reported, chromosomal regions that tend to become abnormal have been recognized. In this study, we investigated abnormalities in chromosomes 8 and 11. There were 27 patients with bladder cancer, 16 males and 11 females, who participated in this study. Abnormalities in chromosomes 8 and 11 were investigated by the fluorescence in situ hybridization (FISH) method. Probes used in this study were chromosome 8α-satellite and chromosome 11α-satellite (Oncor Co.). Of 27 cases, 15 cases were positive for chromosome 8 (55.6%) and ten cases were positive for chromosome 11 (37.0%). Since the FISH method detects chromosomal abnormality by the number of signals generated in cancer cells, this method is objective and simple and thus may be applicable in clinical practice. Springer-Verlag Berlin Heidelberg, 2000 Key words Bladder cancer nationallicence FISH method nationallicence Chromosomal abnormality nationallicence Awata S. Department of Urology, Kousei Hospital, 12-38 Miyukihonmachi Anjyou City Aichi Ken, Japan Tel.:+81-0566-75-2111; Fax:+81-0566-76-4335, JP aut Sakagami H. Department of Urology, Kousei Hospital, 12-38 Miyukihonmachi Anjyou City Aichi Ken, Japan Tel.:+81-0566-75-2111; Fax:+81-0566-76-4335, JP aut Tozawa K. Department of Urology, Nagoya City University, Japan, JP aut Sasaki S. Department of Urology, Nagoya City University, Japan, JP aut Ueda K. Department of Urology, Nagoya City University, Japan, JP aut Kohri K. Department of Urology, Nagoya City University, Japan, JP aut https://doi.org/10.1007/s002409900077 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002409900077 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Awata S. Department of Urology, Kousei Hospital, 12-38 Miyukihonmachi Anjyou City Aichi Ken, Japan Tel.:+81-0566-75-2111; Fax:+81-0566-76-4335, JP aut NATIONALLICENCE 700 1- Sakagami H. Department of Urology, Kousei Hospital, 12-38 Miyukihonmachi Anjyou City Aichi Ken, Japan Tel.:+81-0566-75-2111; Fax:+81-0566-76-4335, JP aut NATIONALLICENCE 700 1- Tozawa K. Department of Urology, Nagoya City University, Japan, JP aut NATIONALLICENCE 700 1- Sasaki S. Department of Urology, Nagoya City University, Japan, JP aut NATIONALLICENCE 700 1- Ueda K. Department of Urology, Nagoya City University, Japan, JP aut NATIONALLICENCE 700 1- Kohri K. Department of Urology, Nagoya City University, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer