caa a22 4500 475742621 CHVBK 20180406123504.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002409900071 doi (NATIONALLICENCE)springer-10.1007/s002409900071 Loss of regulation of circulating 1,25-dihydroxyvitamin D with paradoxically decreased serum phosphate levels in individuals with recurrent kidney stones [Elektronische Daten] [K. Yamakawa, O. E. Franco-Coronel, T. Ohnishi, R. Suzuki, H. Satani, J. Kawamura] A low serum phosphate concentration is characteristic in individuals in whom kidney stones form, this being related to serum 1,25-dihydroxyvitamin D, parathyroid hormone and urinary phosphate excretion. In order to determine whether these parameters are related to recurrence of stone formation, they were analyzed in single and recurrent stone formers as well as controls. An inverse correlation between serum levels of phosphate and 1,25-dihydroxyvitamin D was observed in control subjects, indicating that a drop in serum phosphate results in upregulated circulating 1,25-dihydroxyvitamin D level in controls. While the circulating low phosphate level upregulated the 1,25-dihydroxyvitamin D level in single stone formers, the elevation was less than expected from the drop in serum phosphate in recurrent stone formers. The results thus suggest that loss of upregulation of 1,25-dihydroxyvitamin D by serum levels of phosphate might be important for stone formation. The possibility of deregulation of 1,25-dihydroxyvitamin D to maintain physiological requirements in stone formers and prevent further nephrolithiasis therefore warrants attention. Springer-Verlag Berlin Heidelberg, 2000 Key words 1,25-Dihydroxyvitamin D nationallicence Recurrence of kidney stone formation nationallicence Phosphate nationallicence Stone formers nationallicence Hypercalciuria nationallicence Normocalciuria nationallicence Yamakawa K. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut Franco-Coronel O. E. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut Ohnishi T. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut Suzuki R. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut Satani H. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut Kawamura J. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut https://doi.org/10.1007/s002409900071 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002409900071 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamakawa K. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut NATIONALLICENCE 700 1- Franco-Coronel O. E. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut NATIONALLICENCE 700 1- Ohnishi T. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut NATIONALLICENCE 700 1- Suzuki R. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut NATIONALLICENCE 700 1- Satani H. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut NATIONALLICENCE 700 1- Kawamura J. Department of Urology, Mie University School of Medicine, 2-17 Edobashi, Tsu, Mie 514-8502, Japan Tel.:+81 59 232 1111, ext. 6456 Fax:+81 59 231 5203, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer