caa a22 4500 475742672 CHVBK 20180406123504.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s002400000129 doi (NATIONALLICENCE)springer-10.1007/s002400000129 Poor semen quality from patients with malignancies does not rule out sperm banking [Elektronische Daten] [Jorge Hallak, Ayman Mahran, James Chae, Ashok Agarwal] Cancer therapy can further impair the already poor semen quality in cancer patients. This study evaluated the prefreeze and postthaw semen quality before treatment of patients with malignancies to examine the rationale for sperm banking for these men. Records of nine patients with different malignant tumors, who had been referred for sperm cryopreservation between 1982 and 1997, were reviewed and the results were compared with those of 50 normal healthy donors. Patients did not differ from donors in age, ejaculate volume, or duration of sexual abstinence. The total motile sperm count (median and interquartile range) was significantly different between patients and donors for prefreeze specimens (P=0.026) and postthaw specimens (P=0.008). Also, the percent motility was significantly lower in the patients as compared with the donors in prefreeze (P=0.035) and postthaw specimens (P=0.005). The percentage change in motility after thawing was also larger for patient samples (−54% versus −47%,P=0.39). Other sperm motion characteristics did not significantly differ between the two groups except for postthaw curvilinear velocity (P=0.01). This study concludes that fresh and frozen-thawed semen from patients with malignant tumors is poor in quality but is still adequate for assisted reproductive techniques. As cancer therapy may further impair semen quality, patients should be offered the chance to bank sperm before undergoing cancer therapy. Springer-Verlag Berlin Heidelberg, 2000 Key words Sperm cryopreservation nationallicence cancer nationallicence male infertility nationallicence neoplasm nationallicence Hallak Jorge Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut Mahran Ayman Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut Chae James Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut Agarwal Ashok Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut https://doi.org/10.1007/s002400000129 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400000129 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hallak Jorge Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut NATIONALLICENCE 700 1- Mahran Ayman Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut NATIONALLICENCE 700 1- Chae James Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut NATIONALLICENCE 700 1- Agarwal Ashok Center For Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer