caa a22 4500 475742788 CHVBK 20180406123504.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002400000133 doi (NATIONALLICENCE)springer-10.1007/s002400000133 Bacterial adherence to silver nitrate coated poly- L -lactic acid urological stents in vitro [Elektronische Daten] [Markku Multanen, Martti Talja, Saija Hallanvuo, Anja Siitonen, Tero Välimaa, Teuvo L. J. Tammela, Jukka Seppälä, Pertti Törmälä] The purpose of this study was to see whether it is possible to prevent bacterial adherence to bioabsorbable self-reinforced l-lactic acid polymer (SR-PLLA) urological stents. The SR-PLLA stents were coated with silver nitrate blended ɛ-caprolactone/l-lactide copolymer. The adherence of five bacterial strains (Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and two strains of Escherichia coli) to coated and non-coated SR-PLLA wires were tested. It was found that silver nitrate coating prevented the adherence of bacteria (except E. faecalis) to SR-PLLA stents. The preventive effect correlated with the silver nitrate concentration. It was also found that silver nitrate coating reduced the amount of bacteria in ambient urine. In conclusion, silver nitrate coating may reduce stent-associated bacterial infections by preventing the adherence of bacteria. Further studies are needed to confirm its efficacy and safety in clinical practice. Springer-Verlag Berlin Heidelberg, 2000 Key words Biodegradation nationallicence Infection nationallicence Urology nationallicence Stents nationallicence Multanen Markku Department of Surgery/Division of Urology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, FIN-15850 Lahti, Finland e-mail: am.mutanen@pp.fumnet.fi, Tel.:+358-3-81911 Fax: +358-3-8192117, FI aut Talja Martti Department of Surgery/Division of Urology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, FIN-15850 Lahti, Finland e-mail: am.mutanen@pp.fumnet.fi, Tel.:+358-3-81911 Fax: +358-3-8192117, FI aut Hallanvuo Saija Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland, FI aut Siitonen Anja Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland, FI aut Välimaa Tero Tampere University of Technology, Institute of Biomaterials, Tampere, Finland, FI aut Tammela Teuvo L. J. Division of Urology, Tampere University Hospital, Tampere, Finland, FI aut Seppälä Jukka Helsinki University of Technology, Espoo, Finland, FI aut Törmälä Pertti Tampere University of Technology, Institute of Biomaterials, Tampere, Finland, FI aut https://doi.org/10.1007/s002400000133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400000133 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Multanen Markku Department of Surgery/Division of Urology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, FIN-15850 Lahti, Finland e-mail: am.mutanen@pp.fumnet.fi, Tel.:+358-3-81911 Fax: +358-3-8192117, FI aut NATIONALLICENCE 700 1- Talja Martti Department of Surgery/Division of Urology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, FIN-15850 Lahti, Finland e-mail: am.mutanen@pp.fumnet.fi, Tel.:+358-3-81911 Fax: +358-3-8192117, FI aut NATIONALLICENCE 700 1- Hallanvuo Saija Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Siitonen Anja Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Välimaa Tero Tampere University of Technology, Institute of Biomaterials, Tampere, Finland, FI aut NATIONALLICENCE 700 1- Tammela Teuvo L. J. Division of Urology, Tampere University Hospital, Tampere, Finland, FI aut NATIONALLICENCE 700 1- Seppälä Jukka Helsinki University of Technology, Espoo, Finland, FI aut NATIONALLICENCE 700 1- Törmälä Pertti Tampere University of Technology, Institute of Biomaterials, Tampere, Finland, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer