caa a22 4500 47574280X CHVBK 20180406123504.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002400000120 doi (NATIONALLICENCE)springer-10.1007/s002400000120 Changes in the quantity of collagen type I in women with genuine stress incontinence [Elektronische Daten] [A. Liapis, P. Bakas, A. Pafiti, D. Hassiakos, M. Frangos-Plemenos, G. Creatsas] The aim of this study, was to examine changes in the quantity of collagen type I in the pubocervical fascia of women with genuine stress incontinence (GSI), with and without pelvic relaxation . Seventy-eight patients participated in the study and they were divided into three groups that were comparable with respect to their age and parity. All the patients underwent filling cystometry and patients with detrusor instability were excluded from the study. Biopsies were obtained from the pubocervical fascia. The presence of collagen type I was determined with an immunohistochemical technique. The X-test was used for statistical analysis and a P < 0.05 was considered statistically significant. Collagen type I was significantly reduced in patients with GSI irrespective of the presence or absence of genital prolapse. Thus we found that women with GSI had a significant reduction of collagen type I in the pubocervical fascia which consequently affects the tensile strength of the pubocervical fascia and the support provided to the bladder neck. Springer-Verlag Berlin Heidelberg, 2000 Key words Collagen Type I nationallicence Genuine stress incontinence nationallicence Genital prolapse nationallicence Liapis A. N. Paritsi 9 A, N. Psychiko, Athens, Greece, P.C: 15451 Tel.:+30-1-6727199; Fax:+30-1-6712188, GR aut Bakas P. 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Greece, GR aut Pafiti A. Histopathology Department of Aretaieio Hospital, University of Athens, Greece, GR aut Hassiakos D. 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Greece, GR aut Frangos-Plemenos M. Histopathology Department of Aretaieio Hospital, University of Athens, Greece, GR aut Creatsas G. 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Greece, GR aut https://doi.org/10.1007/s002400000120 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400000120 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liapis A. N. Paritsi 9 A, N. Psychiko, Athens, Greece, P.C: 15451 Tel.:+30-1-6727199; Fax:+30-1-6712188, GR aut NATIONALLICENCE 700 1- Bakas P. 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Greece, GR aut NATIONALLICENCE 700 1- Pafiti A. Histopathology Department of Aretaieio Hospital, University of Athens, Greece, GR aut NATIONALLICENCE 700 1- Hassiakos D. 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Greece, GR aut NATIONALLICENCE 700 1- Frangos-Plemenos M. Histopathology Department of Aretaieio Hospital, University of Athens, Greece, GR aut NATIONALLICENCE 700 1- Creatsas G. 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Greece, GR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer