caa a22 4500 475742885 CHVBK 20180406123504.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002400000137 doi (NATIONALLICENCE)springer-10.1007/s002400000137 Microsatellite analysis in multiple chromosomal regions as a prognostic indicator of primary bladder cancer [Elektronische Daten] [Atsushi Uchida, Masaaki Tachibana, Ayako Miyakawa, Kaoru Nakamura, Masaru Murai] This study investigated gene abnormalities in bladder cancer patients and the relationship between chromosomal alteration and the clinical outcome using microsatellite analysis. A total of 45 human bladder tumor patients were analyzed. The microsatellite markers for 18q21.1 (D18S46, D18S363, and D18S474), 9p21-22 (D9S171, D9S747, D9S1747, and IFNA), and 17p13.1 (TP53) were used for the loss of heterozygosity (LOH) detection. The clinical outcomes were estimated with univariate and multivariate analyses. The results show that patients with LOHs in 18q21.1 and 9p21-22 exhibited a significantly poor prognosis. LOHs of these chromosomal regions had the most predictable potential compared with the other known prognostic factors, such as tumor grade, TNM stage, and age. It is concluded that microsatellite analysis for 18q21.1 and 9p21-22 is capable of predicting the clinical outcome of bladder cancer patients. Springer-Verlag Berlin Heidelberg, 2000 Keywords Loss of heterozygosity nationallicence Microsatellite analysis nationallicence Bladder cancer nationallicence 18q21.1 nationallicence 9p21 nationallicence 22 nationallicence Uchida Atsushi Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut Tachibana Masaaki Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut Miyakawa Ayako Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut Nakamura Kaoru Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut Murai Masaru Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut https://doi.org/10.1007/s002400000137 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400000137 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uchida Atsushi Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut NATIONALLICENCE 700 1- Tachibana Masaaki Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut NATIONALLICENCE 700 1- Miyakawa Ayako Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut NATIONALLICENCE 700 1- Nakamura Kaoru Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut NATIONALLICENCE 700 1- Murai Masaru Department of Urology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan Tel.: +81-3-33531211; Fax: +81-3-32251985, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer