caa a22 4500 475742893 CHVBK 20180406123504.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002400000135 doi (NATIONALLICENCE)springer-10.1007/s002400000135 Altered neural control of micturition in the aged F344 rat [Elektronische Daten] [Toby C. Chai, Karl E. Andersson, Jeremy B. Tuttle, William D. Steers] The purpose of this study was to determine whether micturition reflexes are altered in aged rats. Voiding frequencies and awake cystometrograms (CMGs) were measured in young (3-5 months old) and aged (24 months) F344 male rats. Bladder contractions induced by subcutaneous apomorphine and intravesical capsaicin stimulation were measured using awake CMGs. Urodynamic parameters were compared. Aged rats voided less frequently (4.1 vs 6.9 times/18 h, P=0.006), with a higher volume per void (1.1 vs 0.7 ml, P=0.02) and had a higher micturitional threshold pressure (8.7 vs 4.6 mmHg, P=0.0001) than the young rats. Apomorphine induced a higher frequency of bladder contractions in aged animals compared to young animals (5.5 vs 3.1 contractions/min, P=0.03). Intravesical capsaicin caused a lower pressure bladder response in the aged rats (38.5 vs 70.6 mmHg, P=0.01) compared to the young rats. Bladder afferents and central micturition pathways may be altered in aged rats. Impaired bladder contractility in the elderly may be exacerbated by reduced sensory input, whereas the propensity for detrusor instability could result from altered central processing. This study demonstrated the utility of the F344 animal model to study micturitional changes resulting from aging. Springer-Verlag Berlin Heidelberg, 2000 Key words Aging nationallicence Micturition reflex nationallicence Apomorphine nationallicence Capsaicin nationallicence Rat model nationallicence Chai Toby C. Division of Urology, University of Maryland School of Medicine, 22 S. Greene St., S8D18, Baltimore, MD 21201, USA e-mail: tchai@surgery1.umaryland.edu Tel.: +1-410-3285544; Fax: +1-410-3280595, TP aut Andersson Karl E. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA, US aut Tuttle Jeremy B. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA, US aut Steers William D. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA, US aut https://doi.org/10.1007/s002400000135 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400000135 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chai Toby C. Division of Urology, University of Maryland School of Medicine, 22 S. Greene St., S8D18, Baltimore, MD 21201, USA e-mail: tchai@surgery1.umaryland.edu Tel.: +1-410-3285544; Fax: +1-410-3280595, TP aut NATIONALLICENCE 700 1- Andersson Karl E. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA, US aut NATIONALLICENCE 700 1- Tuttle Jeremy B. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA, US aut NATIONALLICENCE 700 1- Steers William D. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer