caa a22 4500 47574294X CHVBK 20180406123505.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s002400050152 doi (NATIONALLICENCE)springer-10.1007/s002400050152 Effects of phytate and pyrophosphate on brushite and hydroxyapatite crystallization [Elektronische Daten] Comparison with the action of other polyphosphates [F. Grases, M. Ramis, A. Costa-Bauzá] This is a comparative study of the effects of phytate and pyrophosphate and other polyphosphates on the crystallization of hydroxyapatite and brushite, the most frequent calcium phosphates involved in calcium oxalate urolithiasis. Brushite and hydroxyapatite crystal formation was studied in synthetic urine, through kinetic-turbidimetric measurements that allowed evaluation of the inhibitory effects on crystallization of insoluble salts. The effectiveness in preventing brushite crystallization decreases in the sequence phytate > polyphosphate > EDTPO > etidronate > pyrophosphate > triphosphate > medronate; whereas the order of effectiveness in preventing hydroxyapatite crystallization was EDTPO > etidronate=pyrophosphate > triphosphate > medronate > polyphosphate > phytate. Phytate, a natural inhibitor in urine, most effectively blocked brushite precipitation (1.21·10−5 M prevented crystallization during time periods of at least 1 h), and pyrophosphate was the natural inhibitor that most effectively blocked hydroxyapatite precipitation (2.87·10−6 M prevented crystallization during time periods of at least 1 h). This demonstrates that low excretion of these substances would pose a risk of renal lithiasis. Springer-Verlag Berlin Heidelberg, 2000 Key words Phytic acid nationallicence Pyrophosphate nationallicence Diphosphonates nationallicence Crystallization inhibitors nationallicence Hydroxyapatite nationallicence Brushite nationallicence Grases F. Laboratory of Urolithiasis Research, Faculty of Sciences, University of Illes Balears, 07071 Palma de Mallorca, Spain e-mail: dqufgf0@ps.uib.es Tel.: +34-71-173257; Fax: +34-71-173426, ES aut Ramis M. Laboratory of Urolithiasis Research, Faculty of Sciences, University of Illes Balears, 07071 Palma de Mallorca, Spain e-mail: dqufgf0@ps.uib.es Tel.: +34-71-173257; Fax: +34-71-173426, ES aut Costa-Bauzá A. Laboratory of Urolithiasis Research, Faculty of Sciences, University of Illes Balears, 07071 Palma de Mallorca, Spain e-mail: dqufgf0@ps.uib.es Tel.: +34-71-173257; Fax: +34-71-173426, ES aut https://doi.org/10.1007/s002400050152 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002400050152 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grases F. Laboratory of Urolithiasis Research, Faculty of Sciences, University of Illes Balears, 07071 Palma de Mallorca, Spain e-mail: dqufgf0@ps.uib.es Tel.: +34-71-173257; Fax: +34-71-173426, ES aut NATIONALLICENCE 700 1- Ramis M. Laboratory of Urolithiasis Research, Faculty of Sciences, University of Illes Balears, 07071 Palma de Mallorca, Spain e-mail: dqufgf0@ps.uib.es Tel.: +34-71-173257; Fax: +34-71-173426, ES aut NATIONALLICENCE 700 1- Costa-Bauzá A. Laboratory of Urolithiasis Research, Faculty of Sciences, University of Illes Balears, 07071 Palma de Mallorca, Spain e-mail: dqufgf0@ps.uib.es Tel.: +34-71-173257; Fax: +34-71-173426, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer