caa a22 4500 475744128 CHVBK 20180406123508.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1007143113887 doi (NATIONALLICENCE)springer-10.1023/A:1007143113887 Murakami Makoto Musashigaoka College, Yoshimi, Hiki-gun, 355-0154, Saitama, Japan aut Resonant Recognition Model of Neuropeptide Y Family: Hot Spot Amino Acid Distribution in the Sequences [Elektronische Daten] [Makoto Murakami] The resonant recognition model is used to predict structurally and functionally important amino acid residues (so-called hot spots) in the neuropeptide Y (NPY) family. Thirty-three polypeptides belong to this family. All of them consist of 36 amino acids. The model predicts that residues 10 and 28 in the polypeptides are hot spots. In the 33 polypeptides, most of the amino acids at residue 10 are acidic amino acids, glutamic acid and aspartic acid. Other minor amino acids, serine, glycine, and proline, have high probabilities of β-turn occurrence. Amino acids at residue 28 are all branched hydrophobic amino acids, isoleucine, leucine, and valine. The profile for predicting hot spots indicates repeating patterns of residues 1-18 and residues 19-36. Absolute values at residue i and residue i + 18 are the same, but these residues have opposite signs. Therefore the model of the NPY family predicts hot spots concerning a combination of residue i and residue i + 18. Plenum Publishing Corporation, 2000 Fourier transform nationallicence hot spots nationallicence inverse Fourier transform nationallicence neuropeptide Y nationallicence resonant recognition model nationallicence Journal of Protein Chemistry Kluwer Academic Publishers-Plenum Publishers 19/7(2000-10-01), 609-613 0277-8033 19:7<609 2000 19 10930 https://doi.org/10.1023/A:1007143113887 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007143113887 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Murakami Makoto Musashigaoka College, Yoshimi, Hiki-gun, 355-0154, Saitama, Japan aut NATIONALLICENCE 773 0- Journal of Protein Chemistry Kluwer Academic Publishers-Plenum Publishers 19/7(2000-10-01), 609-613 0277-8033 19:7<609 2000 19 10930 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer