caa a22 4500 475744594 CHVBK 20180406123509.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1007026431524 doi (NATIONALLICENCE)springer-10.1023/A:1007026431524 Jésior Jean-Claude TIMC Laboratory, Institut Albert Bonniot, Faculté de Médecine, 38706, La Tronche Cedex, France aut Hydrophilic Framework in Proteins? [Elektronische Daten] [Jean-Claude Jésior] The spatial neighborhood composition of residues was determined in a 511-structure set by taking only side-chain atoms into account to generate a hydrophobicity scale. This scale is symmetrical and has been divided into seven functional groups. Hydrophobic (LIVFMCAWYG) and hydrophilic (PTHSQRNKED) residues obey an equipartition rule: not only are they found in equal proportions, but they play equivalent roles in many of their properties. The nearest neighbors of all residues are always hydrophilic. However, hydrophobic residues are mostly surrounded by other hydrophobic residues located at a peak at 3.9 Å, while hydrophilic residues show three peaks at 5.0, 6.5, and 8.0 Å, suggesting a hydrophilic structural framework. This leads us to question the importance of hydrophobic cores believed to be at the origin of protein folding. Plenum Publishing Corporation, 2000 Protein folding nationallicence hydrophobicity scale nationallicence residue neighborhood nationallicence residue probability nationallicence Journal of Protein Chemistry Kluwer Academic Publishers-Plenum Publishers 19/2(2000-02-01), 93-103 0277-8033 19:2<93 2000 19 10930 https://doi.org/10.1023/A:1007026431524 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007026431524 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Jésior Jean-Claude TIMC Laboratory, Institut Albert Bonniot, Faculté de Médecine, 38706, La Tronche Cedex, France aut NATIONALLICENCE 773 0- Journal of Protein Chemistry Kluwer Academic Publishers-Plenum Publishers 19/2(2000-02-01), 93-103 0277-8033 19:2<93 2000 19 10930 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer