caa a22 4500 475745388 CHVBK 20180406123511.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1005610007209 doi (NATIONALLICENCE)springer-10.1023/A:1005610007209 Variable surface loops and myosin activity: Accessories to a motor [Elektronische Daten] [Coleen Murphy, James Spudich] The catalytic head of myosin is a globular structure that has historically been divided into three segments of 25, 50, and 20 kDa. The solvent-exposed, proteolytically-sensitive surface loops of myosin that join these three segments are highly variable in their sequences. While surface loops have not traditionally been thought to affect enzymatic activities, these loops lie near the ATP and actin-binding sites and have been implicated in the modulation of myosin's kinetic activities. In this work we review the wealth of data regarding the loops that has accumulated over the years and discuss the roles of the loops in contributing to the different activities displayed by different myosin isoforms. Kluwer Academic Publishers, 2000 Murphy Coleen Departments of Biochemistry and Developmental Biology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut Spudich James Departments of Biochemistry and Developmental Biology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut Journal of Muscle Research & Cell Motility Kluwer Academic Publishers 21/2(2000-02-01), 139-151 0142-4319 21:2<139 2000 21 10974 https://doi.org/10.1023/A:1005610007209 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1005610007209 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murphy Coleen Departments of Biochemistry and Developmental Biology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Spudich James Departments of Biochemistry and Developmental Biology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut NATIONALLICENCE 773 0- Journal of Muscle Research & Cell Motility Kluwer Academic Publishers 21/2(2000-02-01), 139-151 0142-4319 21:2<139 2000 21 10974 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer