caa a22 4500 475746147 CHVBK 20180406123514.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s002849910018 doi (NATIONALLICENCE)springer-10.1007/s002849910018 Clarithromycin and Amoxicillin Susceptibility of Helicobacter pylori Strains Isolated from Adult Patients with Gastric or Duodenal Ulcer in Italy [Elektronische Daten] [Laura Franzin, Marco Pennazio, Daniela Cabodi, Francesco Paolo Rossini, Paolo Gioannini] Abstract.: Helicobacter pylori strains, isolated from 100 gastric biopsies from 49 previously untreated adult patients with endoscopy and histology-confirmed gastric or duodenal ulcer, were tested for in vitro antimicrobial susceptibility. Strains were isolated from biopsies of 75.5% (37 of 49) patients before therapy and of 13.5% after therapy. Clarithromycin and amoxicillin susceptibility testing was performed on pretreatment and posttreatment strains by using the agar disk diffusion method and E-test, a quantitative technique for the minimal inhibitory concentration (MIC) determination. All strains (n = 53) were susceptible to amoxicillin by the two methods. Three strains of 34 (8.8%) patients were resistant to clarithromycin: two by both methods and one by E-test (MIC > 2 μg/ml). E-test, although more expensive than the disk diffusion method, is easy to perform and is a reliable method for testing H. pylori susceptibility to antimicrobial agents in the clinical microbiology laboratory. Springer-Verlag New York Inc., 2000 Franzin Laura Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10131 Turin, Italy, IT aut Pennazio Marco Department of Gastroenterology, San Giovanni A.S. Hospital, Via Cavour 31, 10123 Turin, Italy, IT aut Cabodi Daniela Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10131 Turin, Italy, IT aut Paolo Rossini Francesco Department of Gastroenterology, San Giovanni A.S. Hospital, Via Cavour 31, 10123 Turin, Italy, IT aut Gioannini Paolo Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10131 Turin, Italy, IT aut https://doi.org/10.1007/s002849910018 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002849910018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Franzin Laura Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10131 Turin, Italy, IT aut NATIONALLICENCE 700 1- Pennazio Marco Department of Gastroenterology, San Giovanni A.S. Hospital, Via Cavour 31, 10123 Turin, Italy, IT aut NATIONALLICENCE 700 1- Cabodi Daniela Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10131 Turin, Italy, IT aut NATIONALLICENCE 700 1- Paolo Rossini Francesco Department of Gastroenterology, San Giovanni A.S. Hospital, Via Cavour 31, 10123 Turin, Italy, IT aut NATIONALLICENCE 700 1- Gioannini Paolo Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10131 Turin, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer