caa a22 4500 475746554 CHVBK 20180406123515.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002840010162 doi (NATIONALLICENCE)springer-10.1007/s002840010162 Control of Bacillus subtilis Glutamine Synthetase Expression by glnR from Staphylococcus aureus [Elektronische Daten] [Harold J. Schreier, Steven M. Caruso, Kerstin C. Maier] GlnR plays a major role in regulation in Bacillus subtilis by directly controlling expression of glutamine synthetase (GS) as well as several genes involved in nitrogen metabolism. A GlnR homolog from Staphylococcus aureus was found to complement a B. subtilis glnR mutant, regulating GS levels and glnRA expression in a nitrogen-dependent manner. In a GS null mutant, S. aureus GlnR was not able to influence glnRA transcription, indicating that the S. aureus protein is able to respond to the same signals as its B. subtilis counterpart. This is the first demonstration of a relationship between GS and GlnR from a heterologous system and suggests the presence of a regulatory network in S. aureus that responds to changes in environmental nitrogen similar to that described for B. subtilis. Springer-Verlag New York Inc., 2000 Schreier Harold J. Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E. Pratt Street, Baltimore, MD 21202, USA, USA aut Caruso Steven M. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21228, USA, USA aut Maier Kerstin C. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21228, USA, USA aut Current Microbiology Springer-Verlag 41/6(2000-12-01), 425-429 0343-8651 41:6<425 2000 41 284 https://doi.org/10.1007/s002840010162 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002840010162 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schreier Harold J. Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E. Pratt Street, Baltimore, MD 21202, USA, USA aut NATIONALLICENCE 700 1- Caruso Steven M. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21228, USA, USA aut NATIONALLICENCE 700 1- Maier Kerstin C. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21228, USA, USA aut NATIONALLICENCE 773 0- Current Microbiology Springer-Verlag 41/6(2000-12-01), 425-429 0343-8651 41:6<425 2000 41 284 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer