caa a22 4500 475747550 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002810000045 doi (NATIONALLICENCE)springer-10.1007/s002810000045 A role for epithelial γδ T cells in tissue repair [Elektronische Daten] [D. Witherden, S. Rieder, R. Boismenu, Wendy Havran] Conclusions: A balance between epithelial growth and repair versus inflammation to isolate and contain damage is critical for maintenance of the epithelial microenvironment. Epithelial γδ T cells appear to play an important role in maintaining the integrity of the epithelial tissues they survey. Insult to the epithelium likely leads to the up-regulation of self-associated stress molecules that are recognized by intraepithelial γδ T cells. The limited, and in some cases canonical, repertoire of the epithelial γδ TCRs is certainly consistent with this recognition of damaged self, rather than recognition of the vast array of possible non-self antigens that could invade these epithelial barriers. Furthermore, the cellular context of the various γδ T cell subsets and the types of antigens they engage together may contribute to the distinct requirements of γδ T cells for PTKs in their selection, homing and presumably also in their response to epithelial cell damage. Springer-Verlag, 2000 Witherden D. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Rieder S. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Boismenu R. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Havran Wendy Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 265-281 0344-4325 22:3<265 2000 22 281 https://doi.org/10.1007/s002810000045 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000045 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Witherden D. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Rieder S. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Boismenu R. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Havran Wendy Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 265-281 0344-4325 22:3<265 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer