caa a22 4500 475747569 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002810000047 doi (NATIONALLICENCE)springer-10.1007/s002810000047 Intraepithelial γδ T lymphocytes: sentinel cells at mucosal barriers [Elektronische Daten] [David Ferrick, D. King, K. Jackson, R. Braun, S. Tam, D. Hyde, B. Beaman] Conclusions: It is clear that γδ T cells, especially IEL, play more than an accessory role to αβ T cells in immune responses at mucosal borders. They are clearly unique and required for protective immune responses and repair of damaged epithelium. In fact, their role in epithelial surveillance, response and repair may reflect a fundamental role for this lineage of T cells in the overall homeostasis of microenvironments that comprise the mucosal barriers of the host. The consequence of this would make them ideal targets for therapeutic intervention in irreversible and degenerative diseases of the lung and other mucosal environments. In the near future it is anticipated that we will make definitive connections between their physiological stimuli and patterns of responsiveness. Once this is accomplished we may finally be able to construct a more comprehensive map of the functions of T cell immunity in host defense and homeostasis. Springer-Verlag, 2000 Ferrick David Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut King D. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut Jackson K. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut Braun R. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut Tam S. aut Hyde D. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut Beaman B. Department of Medical Microbiology and Immunology, School of Medicine, University of California, 95616, Davis, CA, USA aut Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 283-296 0344-4325 22:3<283 2000 22 281 https://doi.org/10.1007/s002810000047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferrick David Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- King D. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- Jackson K. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- Braun R. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- Tam S. aut NATIONALLICENCE 700 1- Hyde D. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- Beaman B. Department of Medical Microbiology and Immunology, School of Medicine, University of California, 95616, Davis, CA, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 283-296 0344-4325 22:3<283 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer