caa a22 4500 475747577 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002810000048 doi (NATIONALLICENCE)springer-10.1007/s002810000048 γδ T cells in autoimmunity [Elektronische Daten] [Zhinan Yin, Joe Craft] Conclusions: γδ T cells likely play a critical role in the host defenses, and recent evidence has indicated they are important in regulation of the immune response after pathogen challenge. Data are also accumulating that they play a part in autoimmunity and immune regulation. Evidence indicates that γδ T cells mediate these effects through cytokine production, via direct effects on cells of the adaptive immune response, or through interactions with innate immune components or barriers. Nevertheless, the biological function of γδ T cells in immune responses, especially in autoimmunity, largely remains unresolved. Further studies are needed to gain more knowledge about the immunobiology of these cells, asking why precisely they bear an activated phenotype in vivo, how their cytokine production is regulated, and how they interact with other cells of the innate and adaptive immune responses. Springer-Verlag, 2000 Yin Zhinan Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA aut Craft Joe Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA aut Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 311-320 0344-4325 22:3<311 2000 22 281 https://doi.org/10.1007/s002810000048 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000048 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yin Zhinan Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA aut NATIONALLICENCE 700 1- Craft Joe Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 311-320 0344-4325 22:3<311 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer