caa a22 4500 475747615 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002810000041 doi (NATIONALLICENCE)springer-10.1007/s002810000041 γδ cells in got infection, immunopathology, and organogenesis [Elektronische Daten] [C. Miller, S. Roberts, E. Ramsburg, A. Hayday] Conclusions: γδ cells are disproportionately abundant in the gut epithelium of a broad phylogenetic range of vertebrates. The cells respond to infection and seemingly to cell transformation, and via the production of cytokines and/or cytolytic effectors, exert measurable effects on immuno-protection and the course of ensuing immune responses. Consistent with this, γδ cells are implicated in the course of gut immunopathologies such as CD and IBD. These responses of γδ cells are most likely induced by the recognition of either low molecular mass pathogen-encoded antigens, or autologous "stress antigens” expressed by neighboring enterocytes and/or lymphoid cells. The recognition of autologous growth-regulated antigens in the absence of microbial challenge may explain data that indicate a role for γδ cells in the natural development of the gut. This may in turn reflect an evolutionarily ancient yet conserved mode of organogenesis whereby some gut γδ cells develop in situ, largely independently of a thymus. Springer-Verlag, 2000 Miller C. Department of Immunobiology, Guy's King's St Thomas' Medical School, University of London, New Guy's House, Guy's Hospital Campus, London Bridge, SE1 9RT, London, UK aut Roberts S. Department of Molecular Cell and Developmental Biology, Kline Biology Tower, Yale University, 06511, New Haven, CT, USA aut Ramsburg E. Department of Molecular Cell and Developmental Biology, Kline Biology Tower, Yale University, 06511, New Haven, CT, USA aut Hayday A. Department of Immunobiology, Guy's King's St Thomas' Medical School, University of London, New Guy's House, Guy's Hospital Campus, London Bridge, SE1 9RT, London, UK aut Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 297-310 0344-4325 22:3<297 2000 22 281 https://doi.org/10.1007/s002810000041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miller C. Department of Immunobiology, Guy's King's St Thomas' Medical School, University of London, New Guy's House, Guy's Hospital Campus, London Bridge, SE1 9RT, London, UK aut NATIONALLICENCE 700 1- Roberts S. Department of Molecular Cell and Developmental Biology, Kline Biology Tower, Yale University, 06511, New Haven, CT, USA aut NATIONALLICENCE 700 1- Ramsburg E. Department of Molecular Cell and Developmental Biology, Kline Biology Tower, Yale University, 06511, New Haven, CT, USA aut NATIONALLICENCE 700 1- Hayday A. Department of Immunobiology, Guy's King's St Thomas' Medical School, University of London, New Guy's House, Guy's Hospital Campus, London Bridge, SE1 9RT, London, UK aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/3(2000-09-01), 297-310 0344-4325 22:3<297 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer