caa a22 4500 475747690 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002810000053 doi (NATIONALLICENCE)springer-10.1007/s002810000053 Dendritic cell biology and regulation of dendritic cell trafficking by chemokines [Elektronische Daten] [Christophe Caux, Smina Ait-Yahia, Karine Chemin, Odette de Bouteiller, Marie-Caroline Dieu-Nosjean, Bernhard Homey, Catherine Massacrier, Béatrice Vanbervliet, Albert Zlotnik, Alain Vicari] DC (dendritic cells) represent an heterogeneous family of cells which function as sentinels of the immune system. They traffic from the blood to the tissues where, while immature, they capture antigens. Then, following inflammatory stimuli, they leave the tissues and move to the draining lymphoid organs where, converted into mature DC, they prime naive T cells. The key role of DC migration in their sentinel function led to the investigation of the chemokine responsiveness of DC populations during their development and maturation. These studies have shown that immature DC respond to many CC and CXC chemokines (MIP-lα, MIP-iβ, MIP-3α, MIP-5, MCP-3, MCP-4, RANTES, TECK and SDF-1) which are inducible upon inflammatory stimuli. Importantly, each immature DC population displays a unique spectrum of chemokine responsiveness. For examples, Langerhans cells migrate selectively to MIP-3α (via CCR6), blood CDllc+ DC to MCP chemokines (via CCR2), monocytes derived-DC respond to MIP-lα/β (via CCR1 and CCR5), while blood CDllc- DC precursors do not respond to any of these chemokines. All these chemokines are inducible upon inflammatory stimuli, in particular MIP-3α, which is only detected within inflamed epithelium, a site of antigen entry known to be infiltrated by immature DC. In contrast to immature DC, mature DC lose their responsiveness to most of these inflammatory chemokines through receptor down-regulation or desensitization, but acquire responsiveness to ELC/MIP-3β and SLCASCkine as a consequence of CCR7 up-regulation. ELC/MIP-3(3 and SLC/6Ckine are specifically expressed in the T-cell-rich areas where mature DC home to become interdigitating DC. Altogether, these observations suggest that the inflammatory chemokines secreted at the site of pathogen invasion will determine the DC subset recruited and will influence the class of the immune response initiated. In contrast, MIP-3β/6Ckine have a determinant role in the accumulation of antigen-loaded mature DC in T cell-rich areas of the draining lymph node, as illustrated by recent observations in mice deficient for CCR7 or SLC/6Ckine. A better understanding of the regulation of DC trafficking might offer new opportunities of therapeutic interventions to suppress, stimulate or deviate the immune response. Springer-Verlag, 2000 Caux Christophe Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Ait-Yahia Smina Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Chemin Karine Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut de Bouteiller Odette Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Dieu-Nosjean Marie-Caroline Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Homey Bernhard DNAX Research Institute, Palo Alto, California, USA aut Massacrier Catherine Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Vanbervliet Béatrice Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Zlotnik Albert DNAX Research Institute, Palo Alto, California, USA aut Vicari Alain Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut Springer Seminars in Immunopathology Springer-Verlag 22/4(2000-12-01), 345-369 0344-4325 22:4<345 2000 22 281 https://doi.org/10.1007/s002810000053 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000053 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Caux Christophe Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- Ait-Yahia Smina Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- Chemin Karine Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- de Bouteiller Odette Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- Dieu-Nosjean Marie-Caroline Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- Homey Bernhard DNAX Research Institute, Palo Alto, California, USA aut NATIONALLICENCE 700 1- Massacrier Catherine Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- Vanbervliet Béatrice Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 700 1- Zlotnik Albert DNAX Research Institute, Palo Alto, California, USA aut NATIONALLICENCE 700 1- Vicari Alain Schering-Plough Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/4(2000-12-01), 345-369 0344-4325 22:4<345 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer