caa a22 4500 475747704 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810050021 doi (NATIONALLICENCE)springer-10.1007/s002810050021 Modulation of asthmatic response by immunostimulatory DNA sequences [Elektronische Daten] [David Broide, Jae Cho, Marina Miller, Jyothi Nayar, Greg Stachnick, Diego Castaneda, Mark Roman, Eyal Raz] Conclusion: A variety of DNA-based methods of modulating the immune and/or inflammatory response in animal models of asthma have shown significant promise. Antisense strategies seek to inhibit expression of specific host genes, whereas DNA vaccines aim to modulate the immune response to specific encoded allergens. In contrast, ISS DNA therapy seeks to redirect the host immune response from a Th2 to a Th1 response. Current human studies will help to determine which, if any, of these DNA based therapies is a safe and effective therapy for human asthma. Springer-Verlag, 2000 Broide David Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Cho Jae Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Miller Marina Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Nayar Jyothi Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Stachnick Greg Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Castaneda Diego Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Roman Mark Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Raz Eyal Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 117-124 0344-4325 22:1-2<117 2000 22 281 https://doi.org/10.1007/s002810050021 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810050021 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Broide David Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Cho Jae Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Miller Marina Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Nayar Jyothi Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Stachnick Greg Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Castaneda Diego Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Roman Mark Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Raz Eyal Department of Medicine, University of California San Diego, Basic Science Building, Room 5090, 9500 Gilman Drive, 92093-0635, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 117-124 0344-4325 22:1-2<117 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer